| Project/Area Number |
23700642
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Fujita Health University |
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Principal Investigator |
MIZUTANI Kenmei 藤田保健衛生大学, 藤田記念七栗研究所, 講師 (30351068)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 脳梗塞 / リハビリテーション / 薬物併用療法 / 神経可塑性 / 機能回復 |
|---|
| Research Abstract |
It has become widely known that rehabilitation after stroke brings about some improvement of paralysis; however, not much is known about the detailed molecular pathway in the brain. Therefore, identification of molecules related to improvement of paralysis will contribute to establishing a new treatment strategy for stroke rehabilitation. First of all we examined protein expression changes in the cerebral cortex of rat groups with/without exercise after stroke. In the alteration of protein expression profile, NGF, calmodulin and PKC proteins were increased by exercise. Secondly we examined the effects of administration of an activator of PKC, combined with exercise on functional recovery after infarction. In behavioral evaluation using rotarod test, the combination of voluntary exercise and PKC activator administration induced further functional recovery compared with exercise alone, and the behavioral effect seen in administrated animals was dose-dependent.
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