| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
The purpose of this study was to investigate whether oxidative stress is etiology of post-polio syndrome (PPS) . We examined the oxidative stress markers for 27 polio survivors (mean age, 59.3 years) and 13 healthy controls (mean age, 58.0 years). Urinary 8-hydroxydeoxyguanosine (8-OHdG) concentrations were significantly increased with polio survivors as compared to healthy controls. Moreover, urinary 8-isoprostane concentrations were significantly increased with polio survivors with PPS as compared to polio survivors without PPS. These results indicate that the oxidative stress may be etiology of PPS and suggest that 8-isoprostane may provide a biological marker for predicting PPS.
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