Oxidative stress in polio survivors and the patients with post-polio syndrome
| Project/Area Number |
23700655
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ポリオ / ポリオ後症候群 / 酸化ストレス / 8-isoprostane / 8-hydroxydeoxyguanosine / 8-ヒドロキシデオキシグアノシン / リハビリテーション |
|---|
| Research Abstract |
The purpose of this study was to investigate whether oxidative stress is etiology of post-polio syndrome (PPS) . We examined the oxidative stress markers for 27 polio survivors (mean age, 59.3 years) and 13 healthy controls (mean age, 58.0 years). Urinary 8-hydroxydeoxyguanosine (8-OHdG) concentrations were significantly increased with polio survivors as compared to healthy controls. Moreover, urinary 8-isoprostane concentrations were significantly increased with polio survivors with PPS as compared to polio survivors without PPS. These results indicate that the oxidative stress may be etiology of PPS and suggest that 8-isoprostane may provide a biological marker for predicting PPS.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] ポリオ後症候群2014
Author(s)
蜂須賀研二、佐伯覚、松嶋康之、蜂須賀明子
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Journal Title
別冊日本臨床新領域別症候群シリーズ No.27神経症候群(第2版)-その他の神経疾患を含めて-
Pages: 521-524
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