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Identification of development and regulatory mechanisms of spasticity following spinal cord injury

Research Project

Project/Area Number 23700659
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionNational Rehabilitation Center for Persons with Disabilities

Principal Investigator

MORIOKA Kazuhito  国立障害者リハビリテーションセンター(研究所), 研究所 運動機能系障害研究部, 客員研究員 (90551466)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsリハビリテーション / 脳・神経 / 動物 / 細胞・組織
Research Abstract

To identify the mechanism how spasticity, appeared after spinal cord injury (SCI), impairs the recovery of locomotor function, we established the rodent model that develops symptoms of spastic behavior in hindlimb, and developed methods to evaluate spasticity and hyperreflexia. Our findings of a multidisciplinary analysis demonstrated that loss of paretic limb loading early after SCI induced irreversible inhibition of locomotor recovery relating to spasticity, and provided insight into mechanisms in the development of spasticity.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (11 results)

All 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (10 results)

  • [Journal Article] Phosphorylated neurofilament subunit NF-H as a biomarker for evaluating the severity of spinal cord injury patients, a pilot study2012

    • Author(s)
      Hayakawa K, 他
    • Journal Title

      Spinal Cord

      Volume: 50 Issue: 7 Pages: 493

    • DOI

      10.1038/sc.2011.184

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Load-related afferents assume a critical role in the recovery of locomotor function after spinal cord injury2011

    • Author(s)
      Morioka K, Tazoe T, Endoh T, Hayakawa K, Okazaki R, Kawaguchi H, Nakamura K, Ogata T
    • Organizer
      The 41st Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-11-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 血中バイオマーカーによる脊髄損傷の重症度評価の試み2011

    • Author(s)
      緒方 徹、森岡 和仁、飛松 好子、中村 耕三、赤居 正美、岡崎 廉太郎、早川 謙太郎、上野 高明
    • Organizer
      第48回 日本リハビリテーション医学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 脊髄損傷後早期のラットの後肢荷重感覚入力が歩行機能回復に与える影響2011

    • Author(s)
      森岡 和仁、岡崎 廉太郎、早川 謙太郎、上野 高明、中村 耕三、赤居 正美、緒方 徹
    • Organizer
      第48回 日本リハビリテーション医学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 脊髄不全損傷後早期の後肢荷重感覚入力は運動機能回復に影響を及ぼす2011

    • Author(s)
      森岡 和仁、早川 謙太郎、岡崎 廉太郎、川口 浩、中村 耕三、赤居 正美、緒方 徹
    • Organizer
      第26回 日本整形外科学会基礎学術集会
    • Place of Presentation
      群馬
    • Year and Date
      2011-10-20
    • Related Report
      2012 Final Research Report
  • [Presentation] The pivotal role of load-related afferent input for the spontaneous recovery of locomotion after incomplete spinal cord injury2011

    • Author(s)
      Morioka K, Tazoe T, Endoh T, Hayakawa K, Okazaki R, Kawaguchi H, Nakamura K, Ogata T
    • Organizer
      The 29th National Neurotrauma Symposium
    • Place of Presentation
      Florida, USA
    • Year and Date
      2011-07-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 大脳皮質ニューロン活性化と運動療法併用による慢性期脊髄損傷の皮質脊髄路再生誘導に関する研究2011

    • Author(s)
      森岡 和仁、緒方 徹、岩谷 力
    • Organizer
      第48回 日本運動器科学会
    • Place of Presentation
      新潟
    • Year and Date
      2011-07-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Load-related afferents assume a critical role in the recovery of locomotor function after spinal cord injury.2011

    • Author(s)
      森岡 和仁
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Walter E. Washington Convention Center (米国 Washington, DC)
    • Related Report
      2011 Research-status Report
  • [Presentation] 脊髄損傷後早期のラットの後肢荷重感覚入力が歩行機能回復に与える影響2011

    • Author(s)
      森岡 和仁
    • Organizer
      第48回 日本リハビリテーション医学会学術集会
    • Place of Presentation
      幕張メッセ (千葉県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 脊髄不全損傷後早期の後肢荷重感覚入力は運動機能回復に影響を及ぼす2011

    • Author(s)
      森岡 和仁
    • Organizer
      第26回 日本整形外科学会基礎学術集会
    • Place of Presentation
      ベイシア文化ホール (群馬県)
    • Related Report
      2011 Research-status Report
  • [Presentation] The pivotal role of load-related afferent input for the spontaneous recovery of locomotion after incomplete spinal cord injury.2011

    • Author(s)
      森岡 和仁
    • Organizer
      National Neurotrauma Symposium 2011
    • Place of Presentation
      Westin Diplomat Resort & Spa (米国 Florida)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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