Functional role of brain neurotransmitters on exercise capacity and body temperature regulation
| Project/Area Number |
23700773
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | Hiroshima University |
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Principal Investigator |
HASEGAWA Hiroshi 広島大学, 大学院・総合科学研究科, 准教授 (70314713)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 高体温 / 疲労 / カテコールアミン / 視床下部 / マイクロダイアリシス / 持久的運動 / 運動 / 体温上昇 / 神経伝達物質 |
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| Research Abstract |
The purpose of the present study is to investigate the relationship between body temperature regulation and neurotransmitters in the hypothalamus during incremental treadmill running in the rat. Thermoregulatory responses are dependent on the intensity of the exercise and that these responses are associated with changes in noradrenaline and dopamine release, but not in serotonin release in the hypothalamus. The inhibition of brain dopamine by dopamine D1 antagonist influenced endurance exercise capacity and body temperature. These new findings suggest that the catecholamine in the hypothalamus play a important role of exercise-induced hyperthermia and fatigue.
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Report
(3 results)
Research Products
(16 results)
