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Functional role of brain neurotransmitters on exercise capacity and body temperature regulation

Research Project

Project/Area Number 23700773
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Sports science
Research InstitutionHiroshima University

Principal Investigator

HASEGAWA Hiroshi  広島大学, 大学院・総合科学研究科, 准教授 (70314713)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords高体温 / 疲労 / カテコールアミン / 視床下部 / マイクロダイアリシス / 持久的運動 / 運動 / 体温上昇 / 神経伝達物質
Research Abstract

The purpose of the present study is to investigate the relationship between body temperature regulation and neurotransmitters in the hypothalamus during incremental treadmill running in the rat. Thermoregulatory responses are dependent on the intensity of the exercise and that these responses are associated with changes in noradrenaline and dopamine release, but not in serotonin release in the hypothalamus. The inhibition of brain dopamine by dopamine D1 antagonist influenced endurance exercise capacity and body temperature. These new findings suggest that the catecholamine in the hypothalamus play a important role of exercise-induced hyperthermia and fatigue.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (16 results)

All 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (12 results) (of which Invited: 1 results) Remarks (1 results)

  • [Journal Article] Continuous monitoring of hypothalamic neurotransmitters and thermoregulatory responses in exercising rats.2011

    • Author(s)
      Hiroshi Hasegawa, Satomi Takatsu, Takayuki Ishiwata, Hideto Tanaka, Sophie Sarre, Romain Meeusen
    • Journal Title

      Journal of Neuroscience Methods

      Volume: 202 Pages: 119-123

    • NAID

      120005308244

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 体温の調節システムにおける概念の変化2011

    • Author(s)
      長谷川 博, 田中英登
    • Journal Title

      体育の科学

      Volume: 61 Pages: 595-600

    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Journal Article] Continuous monitoring of hypothalamic neurotransmitters and thermoregulatory responses in exercising rats2011

    • Author(s)
      Hasegawa H, Takatsu S, Ishiwata T, Tanaka H, Sarre S, Meeusen R
    • Journal Title

      Journal of Neuroscience Methods

      Volume: 202 Pages: 119-123

    • NAID

      120005308244

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 飼育環境によるラット脳内神経伝達の比較2012

    • Author(s)
      鈴木航太, 二宮千紗, 満石 寿, 柳田信也, 長谷川 博, 石渡貴之
    • Organizer
      第67回日本体力医学会
    • Place of Presentation
      岐阜市
    • Year and Date
      2012-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 運動時の中枢性体温調節機序 -視床下部の役割-2012

    • Author(s)
      長谷川 博
    • Organizer
      第67回日本体力医学会
    • Place of Presentation
      岐阜市
    • Year and Date
      2012-09-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Continuous monitoring of thermoregulatory responses and hypothalamic neurotransmitters during incremental treadmill running in rats2012

    • Author(s)
      Hiroshi Hasegawa, Satomi Takatsu, Takayuki Ishiwata, Hideto Tanaka, Sophie Sarre, Romain Meeusen
    • Organizer
      17thAnnual Congress of European College of Sports Science
    • Place of Presentation
      Bruges, Belgium.
    • Year and Date
      2012-07-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Relationship between serotonin levels in the ventral tegmental area and thermoregulation in freely moving rats2012

    • Author(s)
      Takayuki Ishiwata, Satomi Takatsu, Hiroshi Hasegawa
    • Organizer
      17thAnnual Congress of European College of Sports Science
    • Place of Presentation
      Bruges, Belgium
    • Year and Date
      2012-07-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of acute injection of caffeine on exercise performance, thermoregulation and brain neurotransmission in the rat.2012

    • Author(s)
      Zheng XY, Hiroshi Hasegawa.
    • Organizer
      17thAnnual Congress of European College of Sports Science
    • Place of Presentation
      Bruges, Belgium
    • Year and Date
      2012-07-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 運動時の中枢性体温調節機序 -視床下部の役割-2012

    • Author(s)
      長谷川博
    • Organizer
      第67回日本体力医学会
    • Place of Presentation
      岐阜市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Continuous monitoring of thermoregulatory responses and hypothalamic neurotransmitters during incremental treadmill running in rats.2012

    • Author(s)
      Hasegawa H
    • Organizer
      17th Annual Congress of European College of Sports Science
    • Place of Presentation
      Belgium
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effects of acute injection of caffeine on exercise performance, thermoregulation and brain neurotransmission in the rat.2012

    • Author(s)
      Zheng XY
    • Organizer
      17th Annual Congress of European College of Sports Science
    • Place of Presentation
      Belgium
    • Related Report
      2012 Annual Research Report
  • [Presentation] Relationship between serotonin levels in the ventral tegmental area and thermoregulation in freely moving rats.2012

    • Author(s)
      Ishiwata S
    • Organizer
      17th Annual Congress of European College of Sports Science
    • Place of Presentation
      Belgium
    • Related Report
      2012 Annual Research Report
  • [Presentation] Acute injection of caffeine on thermoregulatory responses 、brain neurotransmitters and endurance exercise capacity in the rat2011

    • Author(s)
      Zheng XY, Hiroshi Hasegawa
    • Organizer
      The 5th Asia-Pacific Conference on Exercise and Sports Science
    • Place of Presentation
      Shanghai, China.
    • Year and Date
      2011-11-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 体温上昇による運動能力の低下と対策2011

    • Author(s)
      長谷川 博
    • Organizer
      第66回日本体力医学会
    • Place of Presentation
      下関市
    • Year and Date
      2011-09-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 体温上昇による運動能力の低下と対策2011

    • Author(s)
      長谷川 博
    • Organizer
      第66回日本体力医学会(招待講演)
    • Place of Presentation
      下関市
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/hasehiro/index.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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