Importance of extracellular proteases in mediating exercise-induced promotion of hippocampal plasticity
| Project/Area Number |
23700775
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | マトリックスメタロプロテイナーゼ / MMP-9 / 低強度運動 / 海馬 / 細胞外環境 / MMP / 運動 / 自発走運動 / 神経新生 / 細胞外プロテアーゼ |
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| Research Abstract |
Matrix metaroproteinase-9 (MMP-9), an extracellular protease, plays a critical role in regulating neuronal function through remodeling of extracellular matrix. In this study, we have investigated whether MMP-9 is involved in exercise-induced promotion of hippocampal plasticity. We found that MMP-9 proteolytic activity in the rat hippocampus was increased at 12 h after a bout of treadmill running at mild intensity, which partially supports our hypothesis. Further studies are needed to examine whether inhibition of MMP-9 activity diminishes exercise-induced promotion of hippocampal plasticity, such as neurogenesis
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Report
(4 results)
Research Products
(24 results)
