| Project/Area Number |
23700776
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | Kyoto Prefectural University |
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Principal Investigator |
AOI Wataru 京都府立大学, 大学院・生命環境科学研究科, 助教 (60405272)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 骨格筋 / マイオカイン / タンパク質 / 大腸がん / 運動 / がん予防 |
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| Research Abstract |
We found a novel muscle-secreted protein, secreted protein acidic and rich in cysteine (SPARC). In this study, I have examined the preventive effect of the novel myokine SPARC on colon tumorigenesis using SPARC-null mouse. As a result, regular low-intensity exercise significantly reduced the formation of the precursor lesions of colon adenocarcinoma in wild-type mice, whereas exercise did not have an inhibitory effect. In addition, regular exercise increased apoptotic activity in the colon of wild-type mice; however, the activity did not differ between sedentary and exercised SPARC-null mice. These results suggest that the secreted-protein SPARC may suppress proliferation of colon tumor cells via increasing caspase activity.
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