| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Locomotor activity, as well as heart rate variability (HRV), were obtained from patients with treatment-resistant depression (TRD) during the period they were subjected to modified electroconvulsive therapy (mECT). The laws of behavioral organization, as quantitative measures of psychomotor activity, did not show any alteration in these patients even before the treatment. This is inconsistent with our previous report using patients with major depressive disorder. In addition, the treatment did not have any effect on locomotor dynamics, while clinical scores were rapidly and dramatically improved with mECT. As for HRV, an index for non-Gaussianity, reflecting activity levels of sympathetic nerve system, showed an increasing tendency with the treatment, suggestive of the enhancement of sympathetic nerve activity. These findings revealed the limitations of these indices as measures of mood disorder and provided insights into psycho-behavioral-pathology in TRD patients, along with the effectiveness of mECT on biological functions.
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