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Towards quantitative evaluation of mood disorders based on biological signals

Research Project

Project/Area Number 23700795
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionThe University of Tokyo

Principal Investigator

NAKAMURA Toru  東京大学, 大学院・教育学研究科, 特任助教 (80419473)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords気分障害 / 身体活動 / 精神行動異常 / 心拍変動 / 自律神経系機能 / 電気痙攣療法 / 心身の健康
Research Abstract

Locomotor activity, as well as heart rate variability (HRV), were obtained from patients with treatment-resistant depression (TRD) during the period they were subjected to modified electroconvulsive therapy (mECT). The laws of behavioral organization, as quantitative measures of psychomotor activity, did not show any alteration in these patients even before the treatment. This is inconsistent with our previous report using patients with major depressive disorder. In addition, the treatment did not have any effect on locomotor dynamics, while clinical scores were rapidly and dramatically improved with mECT. As for HRV, an index for non-Gaussianity, reflecting activity levels of sympathetic nerve system, showed an increasing tendency with the treatment, suggestive of the enhancement of sympathetic nerve activity. These findings revealed the limitations of these indices as measures of mood disorder and provided insights into psycho-behavioral-pathology in TRD patients, along with the effectiveness of mECT on biological functions.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (28 results)

All 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 6 results) Presentation (16 results) (of which Invited: 1 results)

  • [Journal Article] Characterization and modeling of intermittent locomotor dynamics in clock gene-deficient mice2013

    • Author(s)
      T. Nakamura, T. Takumi, A. Takano, F. Hatanaka, Y. Yamamoto
    • Journal Title

      PLoS ONE

      Volume: 8(3) Issue: 3 Pages: e58884-e58884

    • DOI

      10.1371/journal.pone.0058884

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced persistency of resting and active periods of locomotor activity in schizophrenia2012

    • Author(s)
      W. Sano, T. Nakamura, K. Yoshiuchi, T. Kitajima, A. Tsuchiya, Y. Esaki, Y. Yamamoto, N. Iwata
    • Journal Title

      PLoS ONE

      Volume: 7(8) Issue: 8 Pages: e43539-e43539

    • DOI

      10.1371/journal.pone.0043539

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Behavioral organization of locomotor activity and its modeling2012

    • Author(s)
      T. Nakamura, Y. Yamamoto
    • Journal Title

      Proceedings of SCIS&ISIS 2012

      Pages: 1013-1016

    • DOI

      10.1109/scis-isis.2012.6505400

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of intermittent locomotor dynamics in circadian clock gene mutant mice2012

    • Author(s)
      T. Nakamura, T. Takumi, A. Takano, Y.Yamamoto
    • Journal Title

      Proceedings of BSI 2012

      Pages: 9-12

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 身体活動時系列による精神疾患の客観的診断技術の開発2012

    • Author(s)
      中村亨,山本義春
    • Journal Title

      第55回自動制御連合講演会講演論文集

      Pages: 1099-1102

    • Related Report
      2012 Final Research Report
  • [Journal Article] 身体活動における行動組織化とその数理モデル2012

    • Author(s)
      中村亨,山本義春
    • Journal Title

      第56回システム制御情報学会研究発表講演会講演論文集

      Pages: 91-92

    • Related Report
      2012 Final Research Report
  • [Journal Article] Behavioral organization of locomotor activity and its modeling2012

    • Author(s)
      Toru Nakamura
    • Journal Title

      Proceedings of SCIS&ISIS2012

      Volume: - Pages: 1013-1016

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of intermittent locomotor dynamics in circadian clock gene mutant mice2012

    • Author(s)
      Toru Nakamura
    • Journal Title

      Proceedings of BSI'12

      Volume: - Pages: 9-12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 数理科学モデルから精神行動異常を解く2011

    • Author(s)
      中村亨,菊地裕絵,吉内一浩,山本義春
    • Journal Title

      精神科

      Volume: 第18巻,第5号 Pages: 554-559

    • Related Report
      2012 Final Research Report
  • [Journal Article] Behavioral Organization of Locomotor Activity and its Mechanism2011

    • Author(s)
      T. Nakamura, H. Kikuchi, K. Yoshiuchi, T.Takumi, Y. Yamamoto
    • Journal Title

      第26回生体生理工学シンポジウム講演論文集

      Pages: 256-261

    • Related Report
      2012 Final Research Report
  • [Journal Article] 身体活動時系列にみる行動組織化とその生成機序2011

    • Author(s)
      中村亨,内匠透,吉内一浩,山本義春
    • Journal Title

      生体医工学

      Volume: vol.49

    • Related Report
      2012 Final Research Report
  • [Journal Article] 数理科学モデルから精神行動異常を解く2011

    • Author(s)
      中村亨、菊地裕絵、吉内一浩、山本義春
    • Journal Title

      精神科

      Volume: 18(5) Pages: 554-559

    • Related Report
      2011 Research-status Report
  • [Presentation] Behavioral organization of locomotor activity and its modeling2012

    • Author(s)
      T. Nakamura
    • Organizer
      The 6th International Conference on Soft Computing and Intelligent Systems, The 13th International Symposium on Advanced Intelligent Systems
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2012-11-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 身体活動時系列による精神疾患の客観的診断技術の開発2012

    • Author(s)
      中村亨
    • Organizer
      第55回自動制御連合講演会
    • Place of Presentation
      京都
    • Year and Date
      2012-11-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Continuous and quantitative evaluation of locomotor dynamics in bipolar disorder2012

    • Author(s)
      中村亨
    • Organizer
      第14回八ヶ岳シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-11-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 身体活動時系列による双極性障害フェーズ変化の予測可能性2012

    • Author(s)
      中村亨
    • Organizer
      うつ病治療を考える会
    • Place of Presentation
      東京
    • Year and Date
      2012-10-23
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Characterization of intermittent locomotor dynamics in circadian clock gene mutant mice2012

    • Author(s)
      T. Nakamura
    • Organizer
      The 7th International Workshop on Biosignal Interpretation
    • Place of Presentation
      Como, Italy
    • Year and Date
      2012-07-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 身体活動における行動組織化とその数理モデル2012

    • Author(s)
      中村亨
    • Organizer
      第56回システム制御情報学会研究発表講演会
    • Place of Presentation
      京都
    • Year and Date
      2012-05-21
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Behavioral Organization of Locomotor Activity and its Mechanism2011

    • Author(s)
      T. Nakamura
    • Organizer
      第26回生体生理工学シンポジウム
    • Place of Presentation
      滋賀
    • Year and Date
      2011-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Depressed Human Dynamics: Behavioral Organization of Locomotor Activity and its Modeling2011

    • Author(s)
      T. Nakamura
    • Organizer
      33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Boston, USA
    • Year and Date
      2011-09-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 身体活動時系列にみる行動組織化とその生成機序2011

    • Author(s)
      中村亨
    • Organizer
      第50回生体医工学会大会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Depressed Human Dynamics: Behavioral Organization of Locomotor Activity and its Modeling2011

    • Author(s)
      Toru Nakamura
    • Organizer
      33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society(招待講演)
    • Place of Presentation
      Boston, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] 身体活動時系列にみる行動組織化とその生成機序-精神行動異常の統一的理解に向けて2011

    • Author(s)
      中村亨
    • Organizer
      第26回 生体・生理工学シンポジウム
    • Place of Presentation
      滋賀県
    • Related Report
      2011 Research-status Report
  • [Presentation] 身体活動時系列にみる行動組織化とその生成機序2011

    • Author(s)
      中村亨
    • Organizer
      第50回 生体医工学会大会
    • Place of Presentation
      東京都
    • Related Report
      2011 Research-status Report
  • [Presentation] Behavioral organization of locomotor activity and its modeling

    • Author(s)
      Toru Nakamura
    • Organizer
      The 6th International Conference on Soft Computing and Intelligent Systems & The 13th International Symposium on Advanced Intelligent Systems
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] 身体活動時系列による精神疾患の客観的診断技術の開発

    • Author(s)
      中村亨
    • Organizer
      第55回 自動制御連合講演会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Continuous and quantitative evaluation of locomotor dynamics in bipolar disorder

    • Author(s)
      中村亨
    • Organizer
      第14回 八ヶ岳シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Characterization of intermittent locomotor dynamics in circadian clock gene mutant mice

    • Author(s)
      Toru Nakamura
    • Organizer
      The 7th International Workshop on Biosignal Interpretation
    • Place of Presentation
      Como, Italy
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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