Molecular and neural mechanisms of altered autonomic function by fatigue

• Project/Area Number: 23700817
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: MIZUNO Kei 独立行政法人理化学研究所, 分子プローブ動態応用研究チーム, 基礎科学特別研究員 (60464616)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 疲労 / 自律神経 / 交感神経 / 副交感神経 / 脳機能イメージング / fMRI / 分子イメージング / PET / 神経科学 / セロトニン

Research Abstract

Sympathetic hyperactivity during rest is induced by fatigue. However, the molecular and neural mechanisms of the relationship between fatigue and change in autonomic function are unclear. The aim of the present study was to clarify the molecular and neural substrates associated with fatigue and autonomic activity in healthy volunteers using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET). We found that decreases in neural activation and serotonergic function of the cingulate gyrus may be associated with the sympathetic hyperactivity in fatigue condition.

Research Products

• [Journal Article] Effects of daily levels of fatigue and acutely induced fatigue on the visual evoked magnetic response (2012)
  • Author(s): Shigihara, Y., Tanaka, M., Mizuno, K., Ishii, A., Yamano, E., Funakura, M., Kanai, E., Watanabe, Y.
  • Journal Title: Brain Research Volume: 1457 Pages: 44-50
  • Peer Reviewed
• [Journal Article] Changes in reaction time, coefficient of variance of reaction time, and autonomic nerve function in the mental fatigue state caused by long‐term computerized Kraepelin test workload in healthy volunteers (2012)
  • Author(s): Kuratsune, D., Tajima, S., Koizumi, J., Yamaguti, K., Sasabe, T., Mizuno, K., Tanaka, M., Okawa, N., Mito, H., Tsubone, H., Watanabe, Y., Inoue, M., Kuratsune, H
  • Journal Title: World Journal of Neuroscience Volume: 2 Pages: 113-118
  • Peer Reviewed
• [Journal Article] Clinical features of Pittsburgh compound‐B‐negative dementia (2012)
  • Author(s): Takeuchi, J., Shimada, H., Ataka, S., Kawabe, J., Mori, H., Mizuno, K., Wada, Y., Shiomi, S., Watanabe, Y., Miki, T
  • Journal Title: Dementia and Geriatric Cognitive Disorders Volume: 34(2) Pages: 112-120
  • Peer Reviewed
• [Journal Article] Reduction of [11C](+)3‐MPB binding in brain of chronic fatigue syndrome with serum autoantibody against muscarinic cholinergic receptor (2012)
  • Author(s): Yamamoto, S., Ouchi, Y., Nakatsuka, D., Tahara, T., Mizuno, K., Tajima, S., Onoe, H., Yoshikawa, E., Tsukada, H., Iwase, M., Yamaguti, K., Kuratsune, H., Watanabe, Y
  • Journal Title: PLoS One Volume: 7(12)
  • Peer Reviewed
• [Journal Article] Changes in reaction time, coefficient of variance of reaction time, and autonomic nerve function in the mental fatigue state caused by long-term computerized Kraepelin test workload in healthy volunteers (2012)
  • Author(s): Kuratsune Daisuke
  • Journal Title: World Journal of Neuroscience Volume: 2 Issue: 02 Pages: 113-118
  • DOI: 10.4236/wjns.2012.22016
  • Peer Reviewed
• [Journal Article] Clinical features of Pittsburgh compound-B-negative dementia (2012)
  • Author(s): Takeuchi Jun
  • Journal Title: Dementia and Geriatric Cognitive Disorders Volume: 34 Issue: 2 Pages: 112-120
  • DOI: 10.1159/000341577
  • Peer Reviewed
• [Journal Article] Reduction of [11C](+)3-MPB binding in brain of chronic fatigue syndrome with serum autoantibody against muscarinic cholinergic receptor (2012)
  • Author(s): Yamamoto Shigeyuki
  • Journal Title: PLoS One Volume: 7 Issue: 12 Pages: e51515-e51515
  • DOI: 10.1371/journal.pone.0051515
  • Peer Reviewed
• [Journal Article] Mental fatigue caused by prolonged cognitive load associated with sympathetic hyperactivity (2011)
  • Author(s): Mizuno, K., Tanaka, M., Yamaguti, K., Kajimoto, O., Kuratsune, H., Watanabe, Y
  • Journal Title: Behavioral and Brain Functions Volume: 7 Pages: 17-17
  • Peer Reviewed
• [Journal Article] Autonomic nervous alterations associated with daily level of fatigue (2011)
  • Author(s): Tanaka, M., Mizuno, K., Yamaguti, K., Kuratsune, H., Fujii, A., Baba, H., Matsuda, K., Nishimae, A., Takesaka, T., Watanabe, Y
  • Journal Title: Behavioral and Brain Functions Volume: 7 Pages: 46-46
  • Peer Reviewed
• [Journal Article] 機能性ディスペプシア患者の脳内serotonin transporter と消化器症状相関 (2011)
  • Author(s): 富永和作,津本親子,安宅鈴香,越智正博,水野 敬,高橋佳代,谷川徹也,渡辺俊雄,藤原靖弘,塩見 進,渡辺恭良,荒川哲男
  • Journal Title: 消化器心身医学 Volume: 18(1) Pages: 32-38
• [Journal Article] Mental fatigue caused by prolonged cognitive load associated with sympathetic hyperactivity. (2011)
  • Author(s): Mizuno, K., Tanaka, M., Yamaguti, K., Kajimoto, O., Kuratsune, H., Watanabe, Y.
  • Journal Title: Behav Brain Funct Volume: 7 Issue: 1 Pages: 17-17
  • DOI: 10.1186/1744-9081-7-17
  • Peer Reviewed
• [Journal Article] Autonomic nervous alterations associated with daily level of fatigue. (2011)
  • Author(s): Tanaka, M., Mizuno, K., Yamaguti, K., Kuratsune, H., Fujii, A., Baba, H., Matsuda, K., Nishimae, A., Takesaka, T., Watanabe, Y.
  • Journal Title: Behav Brain Funct Volume: 7 Issue: 1 Pages: 46-46
  • DOI: 10.1186/1744-9081-7-46
  • Peer Reviewed
• [Journal Article] 機能性ディスペプシア患者の脳内serotonin transporterと消化器症状相関 (2011)
  • Author(s): 富永和作、津本親子、安宅鈴香、越智正博、水野敬、高橋佳代、谷川徹也、渡辺俊雄、藤原靖弘、塩見進、渡辺恭良、荒川哲男
  • Journal Title: 消化器心身医学 Volume: 18 Pages: 32-38
• [Presentation] Neuroinflammation in patients with chronic fatigue syndrome : a positron emission tomography study with [^<11>C]PK(R)‐11195 (2012)
  • Author(s): Nakatomi, Y., Mizuno, K., Ishi, A., Wada, Y., Tanaka, M., Tazawa, S., Onoe, K., Fukuda, S., Kawabe, J., Takahashi, K., Kataoka, Y., Shiomi, S., Yamaguti, K., Inaba, M., Kuratsune H., Watanabe, Y
  • Organizer: The 35th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2012)
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2012-09-18
• [Presentation] Neuroinflammation in patients with chronic fatigue syndrome: a positron emission tomography study with [11C]PK(R)-11195 (2012)
  • Author(s): Nakatomi Yasuhito
  • Organizer: The 35th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2012)
  • Place of Presentation: Nagoya Congress Center（Nagoya）
• [Presentation] 疲労による自律神経機能の変調 (2011)
  • Author(s): 水野 敬,渡辺恭良
  • Organizer: 第64回日本自律神経学会総会
  • Place of Presentation: 秋田
  • Year and Date: 2011-10-28
• [Presentation] Divided Attention and Childhood Chronic Fatigue Syndrome (CCFS) (2011)
  • Author(s): Mizuno, K., Tanaka, M., Tanabe, H. C., Kawatani, J., Jodoi, T., Tomoda, A., Miike, T., Imai‐Matsumura, K., Sadato, N., Watanabe, Y
  • Organizer: The 34th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2011)
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2011-09-17
• [Presentation] Microglial activation in patients with Chronic Fatigue Syndrome : a Positron Emission Tomography study with [^<11>C]PK11195 (2011)
  • Author(s): Nakatomi, Y., Mizuno, K., Ishi, A., Wada, Y., Tanaka, M., Tazawa, S., Onoe, K., Fukuda, S., Kawabe, J., Takahashi, K., Kataoka, Y., Shiomi, S., Yamaguti, K., Inaba, M., Kuratsune, H., Watanabe, Y
  • Organizer: The 34th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2011)
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2011-09-15
• [Presentation] 小児慢性疲労症候群の脳機能低下のメカニズム (2011)
  • Author(s): 水野 敬
  • Organizer: 第7回日本疲労学会総会・学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-21
• [Presentation] 慢性疲労症候群における脳内ミクログリア活性化:PET 研究 (2011)
  • Author(s): 中富康仁,水野 敬,石井 聡,和田康弘,田中雅彰,田沢周作,尾上嘉代,福田早苗,河邉譲治,高橋和弘,片岡洋祐,塩見進,山口浩二,稲葉雅章,倉恒弘彦,渡邊恭良
  • Organizer: 第7回日本疲労学会総会・学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-21
• [Presentation] 慢性疲労症候群における脳内ミクログリア活性化：PET研究 (2011)
  • Author(s): 中富康仁、水野 敬、石井聡、和田康弘、田中雅彰、田沢周作、尾上嘉代、福田早苗、河邉譲治、高橋和弘、片岡洋祐、塩見 進、山口浩二、稲葉雅章、倉恒弘彦、渡邊恭良
  • Organizer: 第7回日本疲労学会総会・学術集会
  • Place of Presentation: 名古屋大学医学部（名古屋）
• [Presentation] 小児慢性疲労症候群の脳機能低下のメカニズム (2011)
  • Author(s): 水野 敬
  • Organizer: 第7回日本疲労学会総会・学術集会(招待講演)
  • Place of Presentation: 名古屋大学医学部（名古屋）
• [Presentation] Microglial activation in patients with chronic fatigue syndrome: a positron emission tomography study with [11C]PK11195 (2011)
  • Author(s): Nakatomi, Y., Mizuno, K. et al.
  • Organizer: The 34th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2011)
  • Place of Presentation: Pacifico Yokohama (Yokohama)
• [Presentation] Divided attention and childhood chronic fatigue syndrome (CCFS) (2011)
  • Author(s): Mizuno, K.
  • Organizer: The 34th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2011)
  • Place of Presentation: Pacifico Yokohama (Yokohama)
• [Presentation] 疲労による自律神経機能の変調 (2011)
  • Author(s): 水野 敬
  • Organizer: 第64回日本自律神経学会総会(招待講演)
  • Place of Presentation: 秋田ビューホテル（秋田）