| Project/Area Number |
23700828
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Ritsumeikan University (2012-2014)
Kanazawa University (2011) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MASUDA Kazumi 金沢大学, 人間科学系, 教授 (50323283)
HASHIMOTO Takeshi 立命館大学, スポーツ健康科学部, 准教授 (70511608)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ミオグロビン / シグナル伝達 / ミトコンドリア / 骨格筋細胞 |
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| Outline of Final Research Achievements |
Oxygen is essential for human activities. It is needed to generate ATP, which is an energy source consumed by mitochondria inside cells. Myoglobin is a type of protein which assists oxygen transport inside muscle cells, from outside to mitochondria, and stores a large amount of oxygen. The objective of this study was to reveal the regulatory mechanism for myoglobin expression and its physiological significance. According to the results of detailed analyses, it was found that elevation of cyclic AMP concentration inside the skeletal muscle cells was crucial to increase myoglobin expression.
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