Decreased or increased ganglioside converting enzymes by daily exercise in adult mouse model and applied for Alzheimer's disease therapy

• Project/Area Number: 23700829
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Gifu University
• Principal Investigator: HAYASHI Yuichi 岐阜大学, 医学部附属病院, 講師 (00392366)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 運動療法 / St8Sia1 / ガングリオシド変換酵素種 / トレッドミル運動 / アルツハイマー病 / 認知症

Research Abstract

St8Sia1 is one of the important protein concerning about progression of Alzheimer's disease experimental mouse model. The mRNA St8sia1 is down regulated by daily exercise in adult mice. The St8sia1 protein is slightly down regulated by daily exercise in adult mice. This result may be one the mechanisms concerning about anti- progression of Alzheimer's disease with daily exercise patients.

Research Products

• [Journal Article] Evaluation of SLC20A2 mutations that cause idiopathic basal ganglia calcification in Japan (2014)
  • Author(s): Yamada M, Tanaka M, Takagi M, Kobayashi S, Taguchi Y, Takashima S, Tanaka K, Touge T, Tatsuta H, Murayama S, Hayashi Y, Kaneko M, Ishiura H, Mitsui J, Astuta N, Soube G, Shimozawa N, Inuzuka T, Tsuji S, Hozumi I
  • Journal Title: Neurology. Volume: 82 Pages: 705-712
  • Peer Reviewed
• [Journal Article] Evaluation of SLC20A2 mutations that cause idiopathic basal ganglia calcification in Japan. (2014)
  • Author(s): Yamada M, Tanaka M, Takagi M, Kobayashi S, Taguchi Y, Takashima S, Tanaka K, Touge T, Tatsuta H, Murayama S, Hayashi Y, Kaneko M, Ishiura H, Mitsui J, Astuta N, Soube G, Shimozawa N, Inuzuka T, Tsuji S, Hozumi I.
  • Journal Title: Neurology Volume: 82 Pages: 705-712
  • Peer Reviewed
• [Journal Article] Intracranial calcification in a patient with HDR syndrome and a GATA3 mutation (2013)
  • Author(s): Hayashi Y, Suwa T, Inuzuka T
  • Journal Title: Internal Med. Volume: 52 Pages: 161-162
  • NAID: 130003365574
  • Peer Reviewed
• [Journal Article] High frequency of calcification in basal ganglia on brain CT images in Japanese elderly people (2013)
  • Author(s): Yamada M, Asano T, Okamoto K, Hayashi Y, Kanematsu M, Hoshi H, Akaiwa Y, Shimohata T, Nishizawa M, Inuzuka T, Hozumi I
  • Journal Title: Geriatr Gerontol Int. Volume: 13 Pages: 706-710
  • Peer Reviewed
• [Journal Article] Decreased bioelements content in the hair of patients with Fahr's disease (idiopathic bilateral calcification inthe brain) (2013)
  • Author(s): Takagi M, Ozawa K, Yasuda H, Douke M, Hashimoto K, Hayashi Y, Inuzuka T, Hozumi I
  • Journal Title: Biol Trace Elem Res. Volume: 151 Pages: 9-13
  • Peer Reviewed
• [Journal Article] Is there a difference in gastricemptying between myotonic dystrophy type 1 patients with and without gastrointestinal symptoms? (2013)
  • Author(s): Tanaka Y, Kato T, Nishida H, Yamada M, Koumura A, Sakurai T, Hayashi Y, Kimura A, Hozumi I, Araki H, Murase M, Nagaki M, Moriwaki H, Inuzuka T
  • Journal Title: J Neurol. Volume: 260 Pages: 1611-1616
  • Peer Reviewed
• [Journal Article] Corticosteroid therapy in a patient with cerebral amyloid angiopathy-related inflammation (2013)
  • Author(s): Kimura A, Sakurai T, Yoshikura N, Hayashi Y, Takemura M, Takahashi H, Inuzuka T
  • Journal Title: J Neuroinflammation Volume: 10 Pages: 39-39
  • Peer Reviewed
• [Journal Article] Cardiac sympathetic function in the patients with amyotrophic lateral sclerosis : analysis using cardiac [123I] MIBG scintigraphy (2013)
  • Author(s): Tanaka Y, Yamada M, Koumura A, Sakurai T, Hayashi Y, Kimura A, Hozumi I, Inuzuka T
  • Journal Title: J Neurol. Volume: 260 Pages: 2380-2386
  • Peer Reviewed
• [Journal Article] Hayashi Y, Suwa T, Inuzuka T: Intracranial calcification in a patient with HDR syndrome and a GATA3 mutation. (2013)
  • Author(s): Hayashi Y, Suwa T, Inuzuka T
  • Journal Title: Internal Medicine Volume: 52 Pages: 161-162
  • Peer Reviewed
• [Journal Article] Decreased bioelements content in the hair of patients with Fahr’s disease (idiopathic bilateral calcification in the brain). (2013)
  • Author(s): Takagi M, Ozawa K, Yasuda H, Douke M, Hashimoto K, Hayashi Y, Inuzuka T, Hozumi I
  • Journal Title: Biol Trace Elem Res. Volume: 151 Pages: 9-13
  • Peer Reviewed
• [Journal Article] High frequency of calcification in basal ganglia on brain CT images in Japanese elderly people. (2013)
  • Author(s): Yamada M, Asano T, Okamoto K, Hayashi Y, Kanematsu M, Hoshi H, Akaiwa Y, Shimohata T,
  • Journal Title: Geriatr Gerontol Int. Volume: 13 Pages: 706-710
  • Peer Reviewed
• [Journal Article] Is there a difference in gastricemptying between myotonic dystrophy type 1 patients with and without gastrointestinal symptoms? (2013)
  • Author(s): Tanaka Y, Kato T, Nishida H, Yamada M, Koumura A, Sakurai T, Hayashi Y, Kimura A,
  • Journal Title: J Neurology Volume: 260 Pages: 1611-1616
  • Peer Reviewed
• [Journal Article] Corticosteroid therapy in a patient with cerebral amyloid angiopathy-related inflammation. (2013)
  • Author(s): Kimura A, Sakurai T, Yoshikura N, Hayashi Y, Takemura M, Takahashi H, Inuzuka T.
  • Journal Title: J Neuroinflammation Volume: 10 Pages: 39-39
  • Peer Reviewed
• [Journal Article] Intracranial calcification in a patient with HDR syndrome and a GATA3 mutation. (2013)
  • Author(s): Hayashi Y, Suwa T, Inuzuka T
  • Journal Title: Interna Medicine Volume: 52 Pages: 161-162
  • NAID: 130003365574
  • Peer Reviewed
• [Journal Article] Peduncular hallucination in brainstem encephalitis drawn by a patient (2012)
  • Author(s): Hayashi Y, Yoshikura N, Kimura A, Inuzuka T
  • Journal Title: Neurology Volume: 79 Pages: 1625-1625
  • Peer Reviewed
• [Journal Article] Anti-endothelial cell antibodies in patients with cerebral small vessel disease (2012)
  • Author(s): Kimura A, Sakurai T, Yamada M, Koumura A, Hayashi Y, Tanaka Y, Hozumi I, Ohtaki H, Chousa M, Takemura M, Seishima M, Inuzuka T
  • Journal Title: Curr Nerovasc Res. Volume: 9 Pages: 296-301
  • Peer Reviewed
• [Journal Article] Elevated anti-heat shock protein 60 antibody titer is related to white matter hyperintensities (2012)
  • Author(s): Kimura A, Sakurai T, Yamada M, Koumura A, Hayashi Y, Tanaka Y, Hozumi I, Takemura M, Seishima M, Inuzuka T
  • Journal Title: J Stroke Cerebrovasc Dis. Volume: 21 Pages: 305-309
  • Peer Reviewed
• [Journal Article] Late-onset patients with sporadic amyotrophic lateral sclerosis in Japan have a higher progression rate of ALSFRS-R at time of diagnosis (2012)
  • Author(s): Tanaka Y, Yoshikura N, Harada N, Yamada M, Koumura A, Sakurai T, Hayashi Y, Kimura A, Hozumi I, Inuzuka T
  • Journal Title: Internal Med. Volume: 51 Pages: 579-584
  • NAID: 130002061913
  • Peer Reviewed
• [Journal Article] Is there delayed gastric emptying in patients with multiple system atrophy? An analysis using the13C-acetate breath test (2012)
  • Author(s): Tanaka Y, Kato T, Nishida H, Yamada M, Koumura A, Sakurai T, Hayashi Y, Kimura A, Hozumi I, Araki H, Murase M, Nagaki M, Moriwaki H, Inuzuka T
  • Journal Title: J Neurol. Volume: 259 Pages: 1448-1462
  • Peer Reviewed
• [Journal Article] Antibodies against the Tom40 subunit of the translocation of the outer mitochondrial membrane complex and cognitive Impairment in Alzheimer disease (2012)
  • Author(s): Kimura A, Sakurai T, Yamada M, Koumura A, Hayashi Y, Tanaka Y, Hozumi I, Ohtaki H, Chousa M, Takemura M, Seishima M, Inuzuka T
  • Journal Title: J Alzheimers Dis. Volume: 29 Pages: 373-377
  • Peer Reviewed
• [Journal Article] Peduncular hallucinations in brainstem encephalitis drawn by a patient. (2012)
  • Author(s): Hayashi Y, Yoshikura N, Kimura A, Inuzuka T.
  • Journal Title: Neurology Volume: 79 Pages: 1625-1625
  • Peer Reviewed
• [Journal Article] Antibodies against the tom40 subunit of the translocase of the outer mitochondrial membrane complex and cognitive impairment in Alzheimer's disease. (2012)
  • Author(s): Kimura A, Sakurai T, Yamada M, Koumura A, Hayashi Y, Tanaka Y, Hozumi I, Ohtaki H, Chousa M, Takemura M, Seishima M, Inuzuka T.
  • Journal Title: J Alzhimer Disease Volume: 29 Pages: 373-377
  • Peer Reviewed
• [Presentation] Difference in 11C-PIB-PET imaging patters in patients with Alzheimer's disease without microbleeds and those with cerebral amyloid angiopathy (2014)
  • Author(s): Hayashi Y, Shinoda J, Yoshikura N, Waza M, Asano Y, Kimura A, Inuzuka T
  • Organizer: The 66th Annual Meeting of American Academy of Neurology
  • Place of Presentation: Philadelphia, USA
• [Presentation] Difference in 11C-PIB-PET imaging patters in patients with Alzheimer’s disease without (2014)
  • Author(s): Hayashi Y, Shinoda J, Yoshikura N, Waza M, Asano Y, Kimura A, Inuzuka T
  • Organizer: The 66th Annual Meeting of American Academy of Neurology
  • Place of Presentation: Philadelphia, USA
• [Presentation] Multi-professional medication review using computerized medical records helps reduce the numbers of drugs for elderly in-patients. (2013)
  • Author(s): Hayashi Y, Yamada M, Yoshikura N, Harada N, Koumura A, Kimura A, Inuzuka T.
  • Organizer: The 20th International Congress of Geriatrics and Gerontology,
  • Place of Presentation: Seoul, Korea
• [Presentation] トレッドミル運動負荷によるマウス海馬におけるSt8Sia1の発現抑制 (2012)
  • Author(s): 林祐一、橋本和宜、山田恵、保住功、犬塚貴
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-25
• [Presentation] トレッドミル運動負荷によるマウス海馬におけるSt8Sia1の発現抑制 (2012)
  • Author(s): 林 祐一、ほか。
  • Organizer: 日本神経学会学術大会
  • Place of Presentation: 東京
• [Remarks] ２０１２年5月の日本神経学会総会において研究成果について報告する予定である。