Investigation on energy metabolism using transgenic rabbits overexpressing lipoprotein lipase
| Project/Area Number |
23700835
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 肥満 / エネルギー消費 / 二重標識水 / エネルギー代謝 |
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| Research Abstract |
The current study examined energy intake and expenditure, glucosetolerance/insulin action, blood lipid profile, and circulating factors involved in energy metabolism in lipoprotein lipasetransgenic (LPL-Tg) and non-Tg (control) rabbits, andinvestigated mechanisms on the obesity resistance in LPL-Tg rabbits and associations between energy expenditure and glucose/lipid metabolism. Weight was lower in LPL-Tgrabbits despite their higher food intake. The current preliminary analysis on the energy expenditure using doubly labeled water suggested that activation of LPL gene induced an enhancement of energy expenditure. Additionally, the current correlation analysis suggested that increase in energy expenditure induced by LPL activation may be linked with better glucose tolerance and lower triglyceride level.
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Report
(3 results)
Research Products
(2 results)
