The relationship between estrogen-synthesis related gene polymorphisms and exercise-induced reduction of arterial stiffness

• Project/Area Number: 23700841
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Kokugakuin University
• Principal Investigator: HAYASHI Koichiro 國學院大學, 人間開発学部, 准教授 (90433474)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 動脈硬化 / 身体活動 / 遺伝子多型 / エストロゲン

Research Abstract

In the present study, I examined the hypothesis that estrogen synthesis-related gene polymorphisms might influence arterial stiffening and the ability of regular exercise to improve arterial stiffness in Japanese healthy women. In rs4646 and rs1062033 pol

Research Products

• [Journal Article] Effects of regular aerobic exercise on post-exercise vagal reactivation in young female (2013)
  • Author(s): Mariko Nakamura, Koichiro Hayashi, Katsuji Aizawa, Noboru Mesaki, Ichiro Kono
  • Journal Title: European Journal of Sport Science Volume: (in press)
  • Peer Reviewed
• [Journal Article] 女性の動脈硬化と運動(特集動脈硬化と運動・身体活動-予防・改善のための取り組み- (2011)
  • Author(s): 林 貢一郎
  • Journal Title: 臨床スポーツ医学 Volume: 28(12) Pages: 1353-1359
• [Journal Article] 女性の動脈硬化と運動 (2011)
  • Author(s): 林 貢一郎
  • Journal Title: 臨床スポーツ医学 Volume: 28 Pages: 1353-1359
• [Presentation] Higher cardiorespiratory fitness attenuates arterial stiffening associated with the estrogen receptor-beta polymorphism in healthy women (2013)
  • Author(s): Koichiro Hayashi, Motoyuki Iemitsu, Haruka Murakami, Kiyoshi Sanada, Hiroshi Kawano, Yuko Gando, Noriko Tanaka, Motohiko Miyachi
  • Organizer: 18th annual congress of the European College of Sport Science
  • Place of Presentation: Barcelona, Spain
• [Presentation] 閉経前女性におけるエストロゲン受容体α遺伝子多型と動脈硬化指数の関連 (2012)
  • Author(s): 林貢一郎,家光素行,村上晴香,真田樹義,山元健太,河野寛,宮地元彦
  • Organizer: 第67回日本体力医学会大会
  • Place of Presentation: 岐阜
  • Year and Date: 2012-09-16
• [Presentation] 閉経前女性におけるエストロゲン受容体α遺伝子多型と動脈硬化指数の関連 (2012)
  • Author(s): 林貢一郎，家光素行，村上晴香，真田樹義，山元健太，河野寛，宮地元彦
  • Organizer: 第67回日本体力医学会大会
  • Place of Presentation: 岐阜市
• [Presentation] 「音楽を楽しむこと」は頚動脈伸展性を増大させる (2011)
  • Author(s): 林貢一郎
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 下関
  • Year and Date: 2011-09-18
• [Presentation] 動脈硬化に対する運動効果の個人差に関連する遺伝的要因:ゲノムワイド解析 (2011)
  • Author(s): 家光素行,村上晴香,真田樹義,河野寛,丸藤祐子,村上諒子,福典之,林貢一郎,宮地元彦
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 下関
  • Year and Date: 2011-09-17
• [Presentation] Effects of menstrual cycle phase and exercise training type on central arterial compliance in young women. (2011)
  • Author(s): Koichiro Hayashi, Motohiko Miyachi, Jun Sugawara, Hidehiko Komine, Takashi Yokoi, Sho Onodera, Noboru Mesaki
  • Organizer: 16th Annual Meeting of the European College of Sport Science
  • Place of Presentation: Liverpool, UK
  • Year and Date: 2011-07-06
• [Presentation] Genome-wide association study of habitual exercise-induced improvement of arterial stiffness in Japanese adults (2011)
  • Author(s): Motoyuki Iemitsu, Haruka Murakami, Kiyoshi Sanada, Yuko Gando, Ryoko Kawakami, Noriyuki Fuku, Koichiro Hayashi, Motohiko Miyachi
  • Organizer: 58th Annual Meeting and 2nd World Congress on Exercise is Medicine of the American College of Sports Medicine
  • Place of Presentation: Denver, Colorado,USA.
  • Year and Date: 2011-06-02
• [Presentation] 動脈硬化に対する運動効果の個人差に関連する遺伝的要因：ゲノムワイド解析 (2011)
  • Author(s): 家光素行，村上晴香，真田樹義，河野寛，丸藤祐子，村上諒子，福典之，林貢一郎，宮地元彦
  • Organizer: 第66回 日本体力医学会大会
  • Place of Presentation: 山口県下関市
• [Presentation] Effects of menstrual cycle phase and exercise training type on central arterial compliance in young women (2011)
  • Author(s): Koichiro Hayashi, Motohiko Miyachi, Jun Sugawara, Hidehiko Komine, Takashi Yokoi, Sho Onodera, Noboru Mesaki
  • Organizer: 16th Annual Meeting of the European College of Sport Science
  • Place of Presentation: Liverpool, UK
• [Presentation] Genome-wide association study of habitual exercise-induced improvement of arterial stiffness in Japanese adults (2011)
  • Author(s): Motoyuki Iemitsu, Haruka Murakami, Kiyoshi Sanada, Yuko Gando, Ryoko Kawakami, Noriyuki Fuku, Koichiro Hayashi, Motohiko Miyachi
  • Organizer: 58th Annual Meeting and 2nd World Congress on Exercise is Medicine of the American College of Sports Medicine
  • Place of Presentation: Denver, Colorado, USA