Macrophages are associated with exercise-induced increase in insulin sensitivity

• Project/Area Number: 23700842
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Juntendo University
• Principal Investigator: IKEDA Shin-ichi 順天堂大学, 医学研究科, 博士研究員 (50534898)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 運動 / インスリン感受性 / マクロファージ / 骨格筋

Research Abstract

Exercise is a powerful tool to enhance insulin sensitivity in skeletal muscle, however, the precise mechanisms are largely unknown. We hypothesized that macrophages, especially anti-inflammatory M 2 macrophages, are associated with increase in muscle insulin sensitivity after exercise. A single bout of treadmill running increased number of M2 macrophages in skeletal muscle in PBS-ex group. On the other hand, in CL-ex group, number of M2 macrophages were not increased after exercise. Concomitant with change of M2 macrophages, insulin-stimulated 2-DG uptake was increased 24 h after a single bout of exercise in PBS-ex group, however, CL-ex group were not. From these results,we concluded that M2 macrophages are involved in exercise-induced increase in muscle insulin sensitivity.

Research Products

• [Journal Article] Association of macrohage with exercise-induced enhancement of insulin sensitivity in skeletal muscle (2013)
  • Author(s): Shin-ichi Ikeda, Yosifumi Tamura and Hirotaka Watada
  • Journal Title: JPFSM Volume: Vol2, No3
• [Journal Article] Role of macrophages in exercise-induced enhancement of insulin (2013)
  • Author(s): Shin-ichi Ikeda
  • Journal Title: The Journal of Physical Fitness and Sports Medicine Volume: Vo2,2
• [Journal Article] Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men. (2011)
  • Author(s): Sakurai Y, Tamura Y, Takeno K, Kumashiro N, Sato F, Kakehi S, Ikeda S, Ogura Y, Saga N, Naito H, Katamoto S, Fujitani Y, Hirose T, Kawamori R,Watada H
  • Journal Title: Journal of Diabetes Investigation Volume: 2 Issue: 4 Pages: 310-317
  • DOI: 10.1111/j.2040-1124.2010.00091.x
  • Peer Reviewed
• [Presentation] 運動後の筋インスリン感受性亢進に関与するサイトカイン等の探索 (2012)
  • Author(s): 池田 真一、田村 好史、筧 佐織、河盛 隆造、綿田 裕孝
  • Organizer: 第66回日本体力医学会
  • Place of Presentation: 岐阜
• [Presentation] Macrophages are necessary for exercise-induced enhancement of insulin sensitivity in skeletal muscle, (2011)
  • Author(s): Shin-ichi Ikeda. Yoshifumi Tamura, Saori Kakehi, Ryuzo Kawamori, Hirotaka Watada
  • Organizer: The Inaugural International Academy of Sportology
  • Place of Presentation: Tokyo
• [Presentation] 運動による筋インスリン感受性亢進におけるマクロファージの関与 (2011)
  • Author(s): 池田 真一
  • Organizer: 第3回分子骨格筋代謝研究会(招待講演)
  • Place of Presentation: 京都
• [Presentation] Macrophages are necessary for exercise-induced enhancement of insulin sensitivity in skeletal muscle (2011)
  • Author(s): Shin-ichi Ikeda, Yoshifumi Tamura, Saori Kakehi et al
  • Organizer: American Diabetes Association 71st scientific sessions
  • Place of Presentation: SanDiego
• [Presentation] 一過性運動後に認められる筋インスリン感受性亢進にはマクロファージが必須である (2011)
  • Author(s): 池田 真一、田村 好史、筧 佐織ら
  • Organizer: 第65回日本体力医学会
  • Place of Presentation: 山口
• [Presentation] 一過性運動後に認められる筋インスリン感受性亢進にはマクロファージが必須である (2011)
  • Author(s): 池田 真一、田村 好史、筧 佐織ら
  • Organizer: 第61回日本体質医学会総会
  • Place of Presentation: 東京
• [Book] インターロイキン6は、L細胞とα細胞からのGLP-1分泌を介して、インスリン分泌を増加させる (2012)
  • Author(s): 池田真一、田村好史、綿田裕孝
  • Publisher: DIABETES UPDATE
• [Book] DIABETES UPDATE (2012)
  • Author(s): 池田真一、田村好史、綿田裕孝
  • Total Pages: 2
  • Publisher: メディカルレビュー社