| Project/Area Number |
23700849
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
SATO Koji 立命館大学, スポーツ健康科学部, 助教 (20584022)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 性ステロイドホルモン / 糖尿病 / 骨格筋 / 糖代謝 / 栄養成分 / 2型糖尿病 / ジオスゲニン / 性ホルモン |
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| Research Abstract |
In study 1, acute dehydroepiandrosterone (DHEA) administration improves hyperglycemia in rats with streptozotocin (STZ)-induced type 1 diabetes mellitus. Diosgenin, a steroid structurally similar to DHEA (dehydroepiandrosterone), however, it is still unclear whether diosgeninimproves hyperglycemia in the type 1 diabetes model rats through an increase muscular GLUT4 signaling. As a result, diosgenin injections decreased blood glucose level. Moreover, GLUT4 translocation, as well as phosphorylation of Akt and PKC, increased significantly by diosgenin or dioscorea administration.
In study 2, we determined whether chronic diosgenin administration improve insulin resistance in type 2 diabetes model rat. 8-week diosgenin administration significantly improved fasting blood glucose level and insulin resistance. Accordingly, diosgenin administration may be possible new therapetic candidates for type 1 and 2 diabetes.
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