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ChREBP in the lifestyle related disease- The novel mechanism of ChREBP activation-

Research Project

Project/Area Number 23700850
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionHyogo Medical University

Principal Investigator

SAKIYAMA Haruhiko  兵庫医科大学, 医学部, 講師 (30508958)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords生活習慣病 / ChREBP / 転写因子 / 糖代謝 / 糖尿病
Research Abstract

The number of people who suffer from metabolic syndromes, such as overweight, hyperlipemia, diabetes, and high blood pressure. It is known that the abnormalities of sugar and lipid metabolism are participating in the pathogenic mechanism centering on these overweight. Two or more enzyme relate to these metabolism mutually and the transcription factor which promotes the expression of important enzyme especially is ChREBP. In this study, we challenged to solve the activation mechanism of ChREBP andaimed at overweight prevention and development of a curative medicine.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2013 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (11 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Hydrogen peroxide enhances LPS-induced nitric oxide production via the expression of interferon beta in BV-2 microglial cells.2011

    • Author(s)
      Eguchi H, Fujiwara N, Sakiyama H, Yoshihara D, Suzuki K.
    • Journal Title

      Neurosci Lett

      Volume: 494(1) Issue: 1 Pages: 29-33

    • DOI

      10.1016/j.neulet.2011.02.047

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 糖尿病病態下における転写因子ChREBPの新規活性化機構の解明2012

    • Author(s)
      崎山晴彦,藤原範子,江口裕伸,吉原大作,鈴木敬一郎.
    • Organizer
      第22回日本メイラード学会年会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] CarbohydrateResponse Element-binding Protein (ChREBP)の新規活性化因子の探索2012

    • Author(s)
      崎山晴彦, 藤原範子, 江口裕伸, 吉原 大作, 鈴木敬一郎. 転写因子
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] The new insight of transcriptional activation of Carbohydrate Response Element-binding Protein (ChREBP)2012

    • Author(s)
      Haruhiko Sakiyama, Noriko Fujiwara, Hironobu Eguchi, Daisaku Yoshihara, and Keiichiro Suzuki.
    • Organizer
      13th FAOBMB congress of Biochemistry and molecular Biology
    • Place of Presentation
      Bangkok (Thai)
    • Related Report
      2012 Final Research Report
  • [Presentation] The new insight of transcriptional activation of Carbohydrate Response Element-binding Protein (ChREBP)2012

    • Author(s)
      崎山晴彦
    • Organizer
      13th FAOBMB congress of Biochemistry and molecular Biology
    • Place of Presentation
      バンコク タイ
    • Related Report
      2012 Annual Research Report
  • [Presentation] 転写因子Carbohydrate Response Element-binding Protein (ChREBP)の新規活性化因子の探索2012

    • Author(s)
      崎山晴彦
    • Organizer
      第85回日本生化学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 糖尿病病態下における転写因子 ChREBPの新規活性化機構の解明2012

    • Author(s)
      崎山晴彦
    • Organizer
      第22回日本メイラード学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] The role of O-linked GlcNAc modification on the glucose response of ChREBP2011

    • Author(s)
      Haruhiko Sakiyama, Noriko Fujiwara, Takahiro Noguchi, Hironobu Eguchi, Daisaku Yoshihara, and Keiichiro Suzuki
    • Organizer
      12th International Congress On Amino Acids, Peptides and Proteins
    • Place of Presentation
      Beijing (China)
    • Year and Date
      2011-08-15
    • Related Report
      2012 Final Research Report
  • [Presentation] ChREBPのグルコース応答におけるO-GlcNAc修飾の生理的役割2011

    • Author(s)
      崎山晴彦,藤原範子,江口裕伸,吉原大作,鈴木敬一郎.
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] The new insight of transcriptional activation of carbohydrate response element-binding protein (ChREBP)2011

    • Author(s)
      Haruhiko Sakiyama, Noriko Fujiwara, Hironobu Eguchi, Daisaku Yoshihara, and Keiichiro Suzuki.
    • Organizer
      5th Biennial Meeting of Society for Free RadicalResearch-Asia. 8th Conference of AsianSociety for Mitochondrial Research and Medicine. 11th Conference of Japanese Society of Mitochondrial Research and Medicine
    • Place of Presentation
      Kagoshima
    • Related Report
      2012 Final Research Report
  • [Presentation] The role of O-linked GlcNAc modification on the glucose response of ChREBP.2011

    • Author(s)
      Haruhiko Sakiyama, Noriko Fujiwara, Takahiro Noguchi, Hironobu Eguchi, Daisaku Yoshihara, and Keiichiro Suzuki
    • Organizer
      12th International Congress On Amino Acids, Peptides and Proteins
    • Place of Presentation
      北京
    • Related Report
      2011 Research-status Report
  • [Presentation] The new insight of transcriptional activation of carbohydrate response element-binding protein (ChREBP)2011

    • Author(s)
      Haruhiko Sakiyama, Noriko Fujiwara, Hironobu Eguchi, Daisaku Yoshihara, and Keiichiro Suzuki
    • Organizer
      5th Biennial Meeting of Society for Free Radical Research-Asia. 8th Conference of Asian Society for Mitochondrial Research and Medicine.
    • Place of Presentation
      鹿児島
    • Related Report
      2011 Research-status Report
  • [Book] AGEsと老化-糖化制御からみたウェルエイジングー2013

    • Author(s)
      太田博明
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Final Research Report
  • [Book] AGEsと老化ー糖化制御からみたウェルエイジングー2013

    • Author(s)
      太田博明
    • Total Pages
      278
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.hyo-med.ac.jp/department/bchm/index.htm/

    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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