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Antioxidative activity and biotransformation of thiohyantoins derived from isothiocyanates and amino acids

Research Project

Project/Area Number 23700893
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits, studies on eating habits
Research InstitutionNagano Prefectural College

Principal Investigator

TAKAHASHI Asaka  長野県短期大学, 生活科学科, 助手 (90290113)

Co-Investigator(Renkei-kenkyūsha) MATSUOKA Hiroki  高崎健康福祉大学, 教授 (20299837)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsチオヒダントイン / 抗酸化活性 / 安定性 / 抗酸化性
Research Abstract

To clarify the food functions of 3,5-disubstituted 2-thiohydantoins, which were prepared by the reaction of allyl isothiocyanate(AITC), 3-butenyl isothiocyante(3BITC), and4-methylthio-3-butenyl isothiocyanate(MTBITC) with various amino acids, their antioxidative activity was examined. The antioxidative activities of thiohydantoins were evaluated on the basis of several lipid peroxidation model systems and ABTS scavenging property. It appears that the antioxidative activity of the thiohydantoins examined depends on the substituents at position 5 rather than at position3. Further, thiohydantoins were more stabled in the acidic and weakly alkaline pH, it is relativelystable at the high temperature or the coexistence of metal ions.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (3 results)

All 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] ダイコンの抗変異原性物質の同定と定量解析2013

    • Author(s)
      松岡寛樹,須永晃多,宮下さとみ,砂原由佳里,深沢聡美,下田未歩,木村紀久,高橋仁恵,高橋朝歌,平田大介
    • Journal Title

      日本食品科学工学会誌

      Volume: 60 Pages: 117-124

    • Related Report
      2012 Final Research Report
  • [Journal Article] Identification and Quantification of Antimutagenic Compounds in Salted Radish2013

    • Author(s)
      松岡寛樹,須永晃多,宮下さとみ,砂原由佳里,深沢聡美,下田未歩,木村紀久,高橋仁恵,高橋朝歌,平田大介
    • Journal Title

      Nippon Shokuhin Kagaku Kogaku Kaishi

      Volume: 60 Issue: 3 Pages: 117-124

    • DOI

      10.3136/nskkk.60.117

    • NAID

      10031163921

    • ISSN
      1341-027X, 1881-6681
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 大量調理実習室および食品の微生物汚染調査

    • Author(s)
      高橋朝歌,戸井田英子,佐藤晶子,村澤初子,吉岡由美
    • Organizer
      日本食生活学会第44回大会
    • Place of Presentation
      大妻女子大学
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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