Preventive effects of polyphenols on TG-rich lipoprotein-induced vascular inflammation
| Project/Area Number |
23700901
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Ochanomizu University |
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Principal Investigator |
KISHIMOTO Yoshimi お茶の水女子大学, お茶大アカデミック・プロダクション, 寄附研究部門准教授 (70600477)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ポリフェノール / 血管炎症 / 動脈硬化 / TG-richリポ蛋白 |
|---|
| Research Abstract |
Vascular inflammation is well known to be an crucial step in atherosclerosis and also occurs following a fatty meal. The aims of this study was to investigate whether pro-inflammatory aspects of TG-rich lipoprotein could be modulated by polyphenol supplementation. Grape vine polyphenol inhibited the TG-rich lipoprotein-induced inflammation in the human umbilical vein endothelial cells (HUVEC) and THP-1 monocytic cells. Moreover, the supplementation of grape vine polyphenol suppressed the serum lipid increases and inflammatory responses after fatty meal in healthy subjects.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Astaxanthin Enhances ATP-Binding Cassette Transporter A1/G1 Expressions and Cholesterol Efflux from Macrophages2012
Author(s)
Iizuka M, Ayaori M, Uto-Kondo H, Yakushiji E, Takiguchi S, Nakaya K, Hisada T, Sasaki M, Komatsu T, Yogo M, Kishimoto Y, Kondo K, Ikewaki K
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Journal Title
Journal of Nutritional Science and Vitaminology
Volume: 58
Issue: 2
Pages: 96-104
DOI
NAID
ISSN
0301-4800, 1881-7742
Related Report
Peer Reviewed
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[Presentation] Intake of Oligonol Improved LDL Oxidizability and Endothelial Function in Healthy Subjects2011
Author(s)
Kishimoto Y, Tani M, Saita E, Iizuka M, Toyozaki M, Sugihara N, Shiga K, Tanaka Y, Masunaga E, Kitadate K, Wakame K, Kondo K
Organizer
19th International Congress on Nutrition and Integrative Medicine
Place of Presentation
Sapporo
Year and Date
2011-10-15
Related Report
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[Presentation] Intake of Oligonol Improved LDL Oxidizability and Endothelial Function in Healthy Subjects2011
Author(s)
Yoshimi Kishimoto, Mariko Tani, Emi Saita, Maki Iizuka, Miku Toyozaki, Norie Sugihara, Kaedeko Shiga, Yuiko Tanaka, Erika Masunaga, Kentaro Kitadate, Koji Wakame, Kazuo Kondo
Organizer
19th International Congress on Nutrition and Integrative Medicine(招待講演)
Place of Presentation
Sapporo
Related Report
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