Preventive effects of polyphenols on TG-rich lipoprotein-induced vascular inflammation

• Project/Area Number: 23700901
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits, studies on eating habits
• Research Institution: Ochanomizu University
• Principal Investigator: KISHIMOTO Yoshimi お茶の水女子大学, お茶大アカデミック・プロダクション, 寄附研究部門准教授 (70600477)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ポリフェノール / 血管炎症 / 動脈硬化 / TG-richリポ蛋白

Research Abstract

Vascular inflammation is well known to be an crucial step in atherosclerosis and also occurs following a fatty meal. The aims of this study was to investigate whether pro-inflammatory aspects of TG-rich lipoprotein could be modulated by polyphenol supplementation. Grape vine polyphenol inhibited the TG-rich lipoprotein-induced inflammation in the human umbilical vein endothelial cells (HUVEC) and THP-1 monocytic cells. Moreover, the supplementation of grape vine polyphenol suppressed the serum lipid increases and inflammatory responses after fatty meal in healthy subjects.

Research Products

• [Journal Article] Coffee intake mitigated inflammation and obesity-induced insulin resistance in skeletal muscle of high-fat diet-induced obese mice (2014)
  • Author(s): Jia H, Aw W, Egashira K, Takahashi S, Aoyama S, Saito K, Kishimoto Y, Kato H
  • Journal Title: Genes Nutr. Volume: 9 Issue: 3 Pages: 389-389
  • DOI: 10.1007/s12263-014-0389-3
  • Peer Reviewed
• [Journal Article] Consumption of polyphenol-rich juar tea increases endothelium-bound extracellular superoxide dismutase levels in men with metabolic syndrome: link with LDL oxidizability (2013)
  • Author(s): Uto-Kondo H, Ayaori M, Kishimoto Y, Adachi T, Takiguchi S, Yakushiji E, Sasaki M, Komatsu T, Kondo K, Ikewaki K
  • Journal Title: Int. J. Food Sci. Nutr. Volume: 64 Issue: 4 Pages: 407-414
  • DOI: 10.3109/09637486.2012.759185
  • Peer Reviewed
• [Journal Article] Pleiotropic preventive effects of dietary polyphenols in cardiovascular diseases (2013)
  • Author(s): Kishimoto Y, Tani M, Kondo K
  • Journal Title: Eur. J. Clin. Nutr. Volume: 67 Issue: 5 Pages: 532-535
  • DOI: 10.1038/ejcn.2013.29
• [Journal Article] 柑橘類フラボノイドはHepG2細胞における脂質蓄積を減少させる (2013)
  • Author(s): 潮田かおり、才田恵美、杉原規恵、豊﨑美紅、貴堂としみ、谷真理子、岸本良美、近藤和雄
  • Journal Title: 機能性食品と薬理栄養 Volume: 7 Pages: 421-428
  • Peer Reviewed
• [Journal Article] ピーマンの LDLに対する抗酸化作用の検討 (2013)
  • Author(s): 中水優見、岸本良美、才田恵美、杉原規恵、豊﨑美紅、貴堂としみ、谷真理子、近藤和雄
  • Journal Title: 機能性食品と薬理栄養 Volume: 7 Pages: 403-409
  • Peer Reviewed
• [Journal Article] Astaxanthin Enhances ATP-Binding Cassette Transporter A1/G1 Expressions and Cholesterol Efflux from Macrophages (2012)
  • Author(s): Iizuka M, Ayaori M, Uto-Kondo H, Yakushiji E, Takiguchi S, Nakaya K, Hisada T, Sasaki M, Komatsu T, Yogo M, Kishimoto Y, Kondo K, Ikewaki K
  • Journal Title: Journal of Nutritional Science and Vitaminology Volume: 58 Issue: 2 Pages: 96-104
  • DOI: 10.3177/jnsv.58.96
  • NAID: 130002103037
  • ISSN: 0301-4800, 1881-7742
  • Peer Reviewed
• [Journal Article] Antioxidant Activities of Perilla frutescens against Low-Density Lipoprotein Oxidation in Vitro and in Human Subjects (2012)
  • Author(s): Saita E, Kishimoto Y, Tani M, Iizuka M, Toyozaki M, Sugihara N, Kondo K
  • Journal Title: Journal of Oleo Science Volume: 61 Issue: 3 Pages: 113-120
  • DOI: 10.5650/jos.61.113
  • NAID: 130001882214
  • ISSN: 1345-8957, 1347-3352
  • Peer Reviewed
• [Journal Article] アスタキサンチンによる糖脂質代謝調節と動脈硬化 (2012)
  • Author(s): 岸本良美、吉田博、近藤和雄
  • Journal Title: 臨床栄養 Volume: 121 Pages: 505-508
• [Journal Article] Sweet potato (Ipomoea batatas L.) leaves suppressed oxidation of low density lipoprotein (LDL) in vitro and in human subjects (2011)
  • Author(s): Nagai M, Tani M, Kishimoto Y, Iizuka M, Saita E, Toyozaki M, Kamiya T, Ikeguchi M, Kondo K
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 48 Issue: 3 Pages: 203-208
  • DOI: 10.3164/jcbn.10-84
  • NAID: 130004879247
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] レッドビートの抗酸化作用に関する検討 (2011)
  • Author(s): 杉原規恵、岸本良美、才田恵美、飯塚麻貴、豊崎美紅、神山真澄、谷真理子、近藤和雄
  • Journal Title: 機能性食品と薬理栄養 Volume: 6 Pages: 249-254
  • Peer Reviewed
• [Journal Article] ポリフェノールによる動脈硬化予防作用 (2011)
  • Author(s): 岸本良美、谷真理子、近藤和雄
  • Journal Title: 日本未病システム学会誌 Volume: 17 Pages: 95-99
• [Presentation] メタボリックシンドローム予防における抗酸化食品成分の可能性 (2013)
  • Author(s): 岸本良美
  • Organizer: 第11回日本機能性食品医用学会総会
  • Place of Presentation: 東京
• [Presentation] 飽和脂肪酸刺激による血管内皮炎症に対するブドウ若芽ポリフェノールの影響 (2013)
  • Author(s): 岸本良美、中水優見、才田恵美、杉原規恵、谷真理子、近藤和雄
  • Organizer: 第35回日本臨床栄養学会総会第34回日本臨床栄養協会総会第11回大連合大会
  • Place of Presentation: 京都
• [Presentation] Effects of lychee fruits polyphenol on endothelial function after glucose tolerance in healthy subjects (2013)
  • Author(s): Kishimoto Y, Tani M, Saita E, Sugihara N, Toyozaki M, Taguchi C, Kitadate K, Wakame K, Kondo K
  • Organizer: 20th International Congress of Nutrition
  • Place of Presentation: Granada, Spain
• [Presentation] 血管炎症をターゲットに抗酸化食品成分の可能性を探る (2013)
  • Author(s): 岸本良美
  • Organizer: 第45回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京
• [Presentation] Grape vine polyphenol improves dietary fat-induced endothelial dysfunction in vitro and in healthy subjects (2013)
  • Author(s): Kishimoto Y, Tani M, Nakamizu Y, Saita E, Toyozaki M, Sugihara N, Hirai T, Taguchi C, Kondo K
  • Organizer: 8th Asia Pacific Conference on Clinical Nutrition
  • Place of Presentation: Maihama, Japan
• [Presentation] 動脈硬化予防における抗酸化食品成分の可能性 (2013)
  • Author(s): 岸本良美
  • Organizer: 第67回日本栄養・食糧学会大会
  • Place of Presentation: 名古屋
• [Presentation] Effects of lychee fruits polyphenol on endothelial function after glucose tolerance in healthy subjects (2013)
  • Author(s): Kishimoto Y, Tani M, Saita E, Sugihara N, Toyozaki M, Taguchi C, Kitadate K, Wakame K, Kondo K
  • Organizer: 20th International Congress of Nutrition
  • Place of Presentation: Granada Congress Centre (Granada, Spain)
• [Presentation] Grape vine polyphenol improves dietary fat-induced endothelial dysfunction in vitro and in healthy subjects (2013)
  • Author(s): Kishimoto Y, Tani M, Nakamizu Y, Saita E, Toyozaki M, Sugihara N, Hirai T, Taguchi C, Kondo K
  • Organizer: 8th Asia Pacific Conference on Clinical Nutrition
  • Place of Presentation: Tokyo Bay Maihama Hotel Club (Maihama, Chiba)
• [Presentation] 飽和脂肪酸刺激による血管内皮炎症に対するブドウ若芽ポリフェノールの影響 (2013)
  • Author(s): 岸本良美，中水優見，才田恵美，杉原規恵，谷真理子，近藤和雄
  • Organizer: 第35回日本臨床栄養学会総会
  • Place of Presentation: 京都テルサ（京都府京都市）
• [Presentation] メタボリックシンドローム予防における抗酸化食品成分の可能性 (2013)
  • Author(s): 岸本良美
  • Organizer: 第11回日本機能性食品医用学会総会
  • Place of Presentation: 東京海洋大学（東京都港区）
  • Invited
• [Presentation] 血管炎症をターゲットに抗酸化食品成分の可能性を探る (2013)
  • Author(s): 岸本良美
  • Organizer: 第45回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Invited
• [Presentation] 動脈硬化予防における抗酸化食品成分の可能性 (2013)
  • Author(s): 岸本良美
  • Organizer: 第67回日本栄養・食糧学会大会
  • Place of Presentation: 名古屋大学（愛知県名古屋市）
  • Invited
• [Presentation] Acute effect of Oligonol on endothelial function after glucose tolerance (2012)
  • Author(s): Kishimoto Y, Tani M, Saita E, Sugihara N, Toyozaki M, Kitadate K, Wakame K, Kondo K
  • Organizer: 20th International Congress on Nutrition and Integrative Medicine
  • Place of Presentation: Sapporo
• [Presentation] Lychee fruits polyphenol improved endothelial dysfunction induced by glucose tolerance in healthy subjects (2012)
  • Author(s): 岸本良美、谷真理子、才田恵美、杉原規恵、豊崎美紅、北舘健太郎、若命浩二、近藤和雄
  • Organizer: 第44回日本動脈硬化学会
  • Place of Presentation: 福岡
• [Presentation] ブドウ糖負荷後の血管内皮機能に対する低分子化ライチポリフェノールの影響 (2012)
  • Author(s): 岸本良美、谷真理子、才田恵美、杉原規恵、豊崎美紅、北舘健太郎、若命浩二、近藤和雄
  • Organizer: 第66回日本栄養・食糧学会大会
  • Place of Presentation: 仙台
• [Presentation] Oligomerized Lychee Fruits Polyphenol Prevents LDL Oxidation and Endothelial Dysfunction in Vitro and in Healthy Subjects (2012)
  • Author(s): Kishimoto Y, Tani M, Hirata Y, Saita E, Iizuka M, Toyozaki M, Kitadate K, Wakame K
  • Organizer: XVI INTERNATIONAL SYMPOSIUM ON ATHEROSCLEROSIS
  • Place of Presentation: Sydney, Australia
• [Presentation] コレステロール対策と食品 (2012)
  • Author(s): 岸本良美
  • Organizer: 第15回FFF健康食品フォーラム
  • Place of Presentation: 東京
  • Invited
• [Presentation] Intake of Oligonol Improved LDL Oxidizability and Endothelial Function in Healthy Subjects (2011)
  • Author(s): Kishimoto Y, Tani M, Saita E, Iizuka M, Toyozaki M, Sugihara N, Shiga K, Tanaka Y, Masunaga E, Kitadate K, Wakame K, Kondo K
  • Organizer: 19th International Congress on Nutrition and Integrative Medicine
  • Place of Presentation: Sapporo
  • Year and Date: 2011-10-15
• [Presentation] 血管炎症抑制の観点からみたレスベラトロールの抗動脈硬化作用 (2011)
  • Author(s): 岸本良美、谷真理子、近藤和雄
  • Organizer: 第9回日本機能性食品医用学会総会
  • Place of Presentation: 大阪
• [Presentation] LDL被酸化能ならびに血管内皮機能に対するライチ由来ポリフェノール摂取の影響 (2011)
  • Author(s): 岸本良美、谷真理子、才田恵美、豊崎美紅、杉原規恵、志賀楓子、田仲結子、升永えりか、北舘健太郎、若命浩二、近藤和雄
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: 東京
• [Presentation] Intake of Oligonol Improved LDL Oxidizability and Endothelial Function in Healthy Subjects (2011)
  • Author(s): Yoshimi Kishimoto, Mariko Tani, Emi Saita, Maki Iizuka, Miku Toyozaki, Norie Sugihara, Kaedeko Shiga, Yuiko Tanaka, Erika Masunaga, Kentaro Kitadate, Koji Wakame, Kazuo Kondo
  • Organizer: 19th International Congress on Nutrition and Integrative Medicine(招待講演)
  • Place of Presentation: Sapporo
• [Presentation] 血管炎症抑制の観点からみたレスベラトロールの抗動脈硬化作用 (2011)
  • Author(s): 岸本良美、谷真理子、近藤和雄
  • Organizer: 第9回日本機能性食品医用学会総会(招待講演)
  • Place of Presentation: 大阪
• [Book] Functional Food (2012)
  • Author(s): 岸本良美、近藤和雄
  • Total Pages: 99
  • Publisher: フジメディカル出版
• [Book] ポリフェノール:薬用植物および食品の機能性成分 (2012)
  • Author(s): 岸本良美、近藤和雄
  • Total Pages: 277
  • Publisher: シーエムシー出版