Role of non-standard genes in hyperphagia-induced metabolic disease
| Project/Area Number |
23700906
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | The University of Tokushima |
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Principal Investigator |
HARADA Nagakatsu 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (40359914)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 規格外遺伝子 / ナンセンス型 mRNA / ナンセンスコドン依存的 mRNA 分解機構 / 食生活 / 選択的スプライシング / 生活習慣病 / ストレス応答 / NMD / ナンセンス型mRNA / マーカー遺伝子 / 肥満 / NMD機構 / SREBP1delta / 品質管理 / ナンセンスmRNA / ナンセンスコドン依存的mRNA分解機構 / 過食 / UPF1 / eIF2alpha |
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| Research Abstract |
The results of this study show that theexpression levels of non-standard genes (nonsense mRNAs) were increased in several tissues (including kidney and brown adipose tissue) of hyperphagia-induced obese mice. Functional analysis of proteins derived from the nonsense mRNAs suggested the possibility that the non-standard genes play roles in the development of obesity and metabolic disease.
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Report
(3 results)
Research Products
(3 results)
