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Role of non-standard genes in hyperphagia-induced metabolic disease

Research Project

Project/Area Number 23700906
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits, studies on eating habits
Research InstitutionThe University of Tokushima

Principal Investigator

HARADA Nagakatsu  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (40359914)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords規格外遺伝子 / ナンセンス型 mRNA / ナンセンスコドン依存的 mRNA 分解機構 / 食生活 / 選択的スプライシング / 生活習慣病 / ストレス応答 / NMD / ナンセンス型mRNA / マーカー遺伝子 / 肥満 / NMD機構 / SREBP1delta / 品質管理 / ナンセンスmRNA / ナンセンスコドン依存的mRNA分解機構 / 過食 / UPF1 / eIF2alpha
Research Abstract

The results of this study show that theexpression levels of non-standard genes (nonsense mRNAs) were increased in several tissues (including kidney and brown adipose tissue) of hyperphagia-induced obese mice. Functional analysis of proteins derived from the nonsense mRNAs suggested the possibility that the non-standard genes play roles in the development of obesity and metabolic disease.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (3 results)

All 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Identification and functional characterization of human glycerol-3-phosphate acyltransferase 1 gene promoters.2012

    • Author(s)
      Nagakatsu Harada et al.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 423 Issue: 1 Pages: 128-133

    • DOI

      10.1016/j.bbrc.2012.05.094

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Membrane topology of murine glycerol-3-phosphate acyltransferase 22012

    • Author(s)
      Nakagawa T, Sakaue H, et al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: Vol.418 Issue: 3 Pages: 506-511

    • DOI

      10.1016/j.bbrc.2012.01.055

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 脂質合成律速酵素 GPAT2 の膜トポロジー解析2011

    • Author(s)
      中川 忠彦,原田 永勝,吉田 将紀,宮本 愛子,川西 由希子,阪上 浩,中屋 豊
    • Organizer
      第32回日本肥満学会
    • Place of Presentation
      兵庫
    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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