The effect of trans fatty acids on carcinogenesis in the liver and antigen-specific adaptive immune responses

• Project/Area Number: 23700907
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits, studies on eating habits
• Research Institution: Ehime University
• Principal Investigator: MIYAKE Teruki 愛媛大学, 大学院・医学系研究科, 講師 (80573659)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: トランス脂肪酸 / 脂肪 / 免疫

Research Abstract

Absolute mechanism of trans fatty acid on its negative effect to the liver is unknown. We investigated the effect of trans fatty acid on liver carcinogenesis from immunity and oxidative stress standpoint using high trans fatty acid diet fed mice. Antigen-specific immunity was decreased comparedto the control diet, but did not differ among mice fed by other high fatty acid diets. However, oxidant stress and carcinogenesis of the liver was significantly increased in mice fed by high trans fatty acid diet compared to the control diet and other high fatty acid diets.

Research Products

• [Journal Article] Nonalcoholic fatty liver disease: Factors associated with its presence and onset. (2013)
  • Author(s): Miyake T, Kumagi T, Furukawa S, Tokumoto Y, Hirooka M, Abe M, Hiasa Y, Matsuura B, Onji M
  • Journal Title: J Gastroenterol Hepatol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Body Mass Index as the Predictive Factor for the Onset of Nonalcoholic Fatty Liver Disease: A Community-based Retrospective Longitudinal Cohort Study. (2013)
  • Author(s): Miyake T, Kumagi T, Hirooka M, Furukawa S, Koizumi M, Tokumoto Y, Ueda T, Yamamoto S, Abe M, Kitai K, Hiasa Y, Matsuura B, Onji M.
  • Journal Title: J Gastroenterol Volume: 48 Issue: 3 Pages: 413-422
  • DOI: 10.1007/s00535-012-0650-8
  • Peer Reviewed
• [Journal Article] 【生活習慣と肝胆膵疾患】 非アルコール性脂肪性肝疾患に関わる生活習慣リスク因子(解説/特集) (2013)
  • Author(s): 三宅 映己, 徳本 良雄, 恩地 森一
  • Journal Title: 消化器内科(1884-2895) Volume: 56巻 1号 Pages: 99-103
• [Journal Article] 非アルコール性脂肪性肝疾患に関わる生活習慣リスク因子 (2013)
  • Author(s): 三宅 映己
  • Journal Title: 消化器内科 Volume: 56 Pages: 99-103
• [Journal Article] Nonalcoholic fatty liver disease: Factors associated with its presence and onset (2013)
  • Author(s): Teruki Miyake
  • Journal Title: Journal of Gastroenteroly and Hepatology Volume: in press
  • Peer Reviewed
• [Journal Article] Reply to the letter by Lai et al. regarding "Body mass index is the most useful predictive factor for the onset of nonalcoholic fatty liver disease: a community-based retrospective longitudinal study" (2013)
  • Author(s): Teruki Miyake
  • Journal Title: Journal of Gastroenteroly Volume: in press
  • NAID: 10031169231
  • Peer Reviewed
• [Journal Article] B cell-activating factor is associated with the histological severity of nonalcoholic fatty liver disease (2013)
  • Author(s): Teruki Miyake
  • Journal Title: Hepatology international Volume: in press
  • Peer Reviewed
• [Journal Article] Reply to the letter by Lai et al. regarding "Body mass index is the most useful predictive factor for the onset of nonalcoholic fatty liver disease: a community-based retrospective longitudinal study" (2012)
  • Author(s): Miyake T, Kumagi T, Furukawa S, Abe M, Hiasa Y, Matsuura B, Onji M
  • Journal Title: J Gastroenterol
  • NAID: 10031169231
  • Peer Reviewed
• [Journal Article] B cell-activating factor is associated with the histological severity of nonalcoholic fatty liver disease (2012)
  • Author(s): Miyake T, Abe M, Tokumoto Y, Hirooka M, Furukawa S, Kumagi T, Hamada M, Kawasaki K, Tada F, Ueda T, Hiasa Y, Matsuura B, Onji M
  • Journal Title: Hepatol Int
  • Peer Reviewed
• [Journal Article] High Serum Palmitic Acid is Associated with Low Antiviral Effects of Interferon-Based Therapy for Hepatitis C Virus. (2012)
  • Author(s): Miyake T, Hiasa Y, Hirooka M, Tokumoto Y, Watanabe T, Furukawa S, Ueda T, Yamamoto S, Kumagi T, Miyaoka H, Abe M, Matsuura B, Onji M.
  • Journal Title: Lipids Volume: 47 Issue: 11 Pages: 1053-1062
  • DOI: 10.1007/s11745-012-3716-8
  • Peer Reviewed
• [Journal Article] Long-term branched-chain amino acid supplementation improves glucose tolerance in patients with nonalcoholic steatohepatitis-related cirrhosis (2012)
  • Author(s): Miyake T, Abe M, Furukawa S, Tokumoto Y, Toshimitsu K, Ueda T, Yamamoto S, Hirooka M, Kumagi T, Hiasa Y, Matsuura B, Onji M
  • Journal Title: Intern Med Volume: 51(16) Pages: 2151-5
  • NAID: 130002062298
  • Peer Reviewed
• [Journal Article] 【最新臨床糖尿病学 下-糖尿病学の最新動向-】 糖尿病合併症・糖尿病関連疾患 糖尿病に起因、関連する疾患 NAFLD、NASH(解説/特集) (2012)
  • Author(s): 三宅 映己, 恩地 森一
  • Journal Title: 日本臨床(0047-1852) Volume: 70巻増刊 5 最新臨床糖尿病学(下) Pages: 528-532
• [Journal Article] Metabolic Markers and ALT Cutoff Level for Diagnosing Nonalcoholic Fatty Liver Disease: A Community-based Cross-sectional Study. (2012)
  • Author(s): Miyake T, Kumagi T, Hirooka M, Koizumi M, Furukawa S, Ueda T, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Hiasa Y, Matsuura B, Onji M.
  • Journal Title: J Gastroenterol Volume: 47 Issue: 6 Pages: 696-703
  • DOI: 10.1007/s00535-012-0534-y
  • NAID: 10030802769
  • Peer Reviewed
• [Journal Article] Long-term branched-chain amino acid supplementation improves glucose tolerance in patients with nonalcoholic steatohepatitis-related cirrhosis (2012)
  • Author(s): Teruki Miyake
  • Journal Title: Internal Medicine Volume: 51 Pages: 2151-2155
  • NAID: 130002062298
  • Peer Reviewed
• [Journal Article] 糖尿病合併症・糖尿病関連疾患 糖尿病に起因、関連する疾患 NAFLD、NASH (2012)
  • Author(s): 三宅 映己
  • Journal Title: 日本臨床 Volume: 70 Pages: 528-532
• [Journal Article] B cell-activating factor controls the production of adipokines and induces insulin resistance. (2011)
  • Author(s): Hamada M, Abe M, Miyake T, Kawasaki K, Tada F, Furukawa S, Matsuura B, Hiasa Y, Onji M・
  • Journal Title: Obesity Volume: 19 Pages: 1915-22
  • Peer Reviewed
• [Presentation] 非アルコール性脂肪性肝疾患(NAFLD)発症において BMI は最も有用な予測因子である (2013)
  • Author(s): 三宅 映己, 徳本 良雄, 阿部雅則
  • Organizer: 第99回日本消化器病学会総会
  • Place of Presentation: 鹿児島市
• [Presentation] 非アルコール性脂肪性肝疾患(NAFLD)発症においてBMIは最も有用な予測因子である (2013)
  • Author(s): 三宅 映己
  • Organizer: 第99回日本消化器病学会総会
  • Place of Presentation: 鹿児島市
• [Presentation] B cell activator factor (BAFF)と NAFLD の肝組織所見との関連 (2012)
  • Author(s): 三宅映己,上田晃久,山本晋,阿部雅則,徳本良雄,多田藤政,川崎敬太郎,濱田麻穂,古川慎哉,日浅陽一,松浦文三,恩地森一
  • Organizer: 第2回肥満と消化器疾患研究会
  • Place of Presentation: 東京都
  • Year and Date: 2012-04-21
• [Presentation] B cell activating factor is associated with the histological severity of nonalcoholic fatty liver disease. (2012)
  • Author(s): Miyake T, Furukawa S, Abe M, Kawasaki K, Tada F, Yamamoto S, Kumagi T, Hiasa Y, Matsuura B, Onji M
  • Organizer: 9th IDF-WPR Congress and 4th AASD Meeting
  • Place of Presentation: Kyoto
• [Presentation] High serum palmitic acid levels are associated with the low antiviral effect of interferon-based therapy in patients infected with Hepatitis C virus (2012)
  • Author(s): Miyake T, Hiasa Y, Tokumoto Y, Hirooka M, Watanabe T, Furukawa S, Kumagi T, Abe M, Matsuura B, Onji M
  • Organizer: The 10th JSH Single Topic Conference
  • Place of Presentation: Tokyo
• [Presentation] The predictive factor for the onset of nonalcoholic fatty liver disease. (2012)
  • Author(s): Miyake T, Kumagi T, Furukawa S, Hirooka M, Koizumi M, Tokumoto Y, Yamamoto S, Abe M, Hiasa Y, Matsuura B, Onji M
  • Organizer: 3rd Asian-Pacific Topic Conference
  • Place of Presentation: Tokyo
• [Presentation] Induction of Insulin Resistance by B Cell Activating Factor (BAFF) via Alternation in Adipokine Production. (2012)
  • Author(s): Miyake T, Abe M, Furukawa S, Hamada M, Ueda T, Yamamoto S, Niiya T, Kumagi T, Hiasa Y, Matsuura B, Onji M
  • Organizer: American Diabetes Association's 72nd Scientific Sessions.
  • Place of Presentation: Philadelphia, USA
• [Presentation] Metabolic Markers and ALT Cutoff Level for Diagnosing Nonalcoholic Fatty Liver Disease in Japanese: A Community-based Cross-sectional Study (2012)
  • Author(s): Miyake T, Kumagi T, Hirooka M, Koizumi M, Furukawa S, Koizumi M, Ueda T, Tokumoto Y, Ikeda Y, Abe M, Kohichiro Kitai, Hiasa Y, Matsuura B, Onji M
  • Organizer: Digestive Disease Week 2012
  • Place of Presentation: San Diego. USA
• [Presentation] 非アルコール性脂肪性肝疾患(NAFLD)に関わる生活習慣リスク因子の解析 (2012)
  • Author(s): 三宅 映己, 徳本 良雄, 恩地 森一
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 東京都
• [Presentation] B cell activating factor is associated with the histological severity of nonalcoholic fatty liver disease (2012)
  • Author(s): Teruki Miyake
  • Organizer: 9th IDF-WPR Congress and 4th AASD Meeting
  • Place of Presentation: 京都
• [Presentation] High serum palmitic acid levels are associated with the low antiviral effect of interferon-based therapy in patients infected with Hepatitis C virus. (2012)
  • Author(s): Teruki Miyake
  • Organizer: The 10th JSH Single Topic Conference
  • Place of Presentation: 東京
• [Presentation] The predictive factor for the onset of nonalcoholic fatty liver disease (2012)
  • Author(s): Teruki Miyake
  • Organizer: 3rd Asian-Pacific Topic Conference
  • Place of Presentation: 東京
• [Presentation] Induction of Insulin Resistance by B Cell Activating Factor (BAFF) via Alternation in Adipokine Production (2012)
  • Author(s): Teruki Miyake
  • Organizer: American Diabetes Association’s 72nd Scientific Sessions
  • Place of Presentation: Philadelphia, USA.
• [Presentation] Metabolic Markers and ALT Cutoff Level for Diagnosing Nonalcoholic Fatty Liver Disease in Japanese: A Community-based Cross-sectional Study (2012)
  • Author(s): Teruki Miyake
  • Organizer: Digestive Disease Week 2012
  • Place of Presentation: San Diego. USA.
• [Presentation] B cell activator factor (BAFF)とNAFLDの肝組織所見との関連 (2012)
  • Author(s): 三宅 映己
  • Organizer: 第2回肥満と消化器疾患研究会
  • Place of Presentation: 東京都
• [Presentation] 牛乳乳製品摂取習慣が糖尿病発症予防へ与える影響に関する多施設共同研究 (2012)
  • Author(s): 古川慎哉, 清水広樹, 三宅映己, 松浦文三, 恩地森一
  • Organizer: 第15回日本病態栄養学会年次学術集会
  • Place of Presentation: 京都
• [Presentation] 耐糖能異常発症予測因子の検討 肝疾患スクリーニング検査をもとに (2011)
  • Author(s): 三宅 映己, 古川 慎哉, 上田 晃久, 山本 晋, 真柴 寿枝, 宮岡 弘明, 酒井 武則, 中西 征司, 恩地 森一, 松浦 文三
  • Organizer: 日本糖尿病学会中四国地方会49回総会
  • Place of Presentation: 徳島市
• [Presentation] 非アルコール性脂肪肝炎(NASH)に対する栄養療法の有用性 (2011)
  • Author(s): 三宅映己, 松浦文三, 古川慎哉, 恩地森一, 利光久美子, 永井祥子
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 北海道
• [Presentation] 慢性甲状腺炎が非アルコール性脂肪性肝疾患(NAFLD)患者の病態に与える影響の検討 (2011)
  • Author(s): 三宅映己, 古川慎哉, 上田晃久, 新谷哲司, 宮岡弘明, 酒井武則, 恩地森一, 松浦文三
  • Organizer: 第54回日本甲状腺学会学術集会
  • Place of Presentation: 大阪