| Project/Area Number |
23700909
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Yamagata University |
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Principal Investigator |
SUZUKI Takuji 山形大学, 教育文化学部, 助教 (50587110)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 小腸機能回復 / 経腸栄養法 / 中心静脈栄養法 / 絨毛萎縮 / 管腔内栄養素流入刺激 / 細胞増殖 / 小腸機能 / 栄養学 / 栄養素 / 中心静脈栄養法（TPN） |
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| Research Abstract |
We analyzed underlying mechanism of villus atrophy by non-influx of nutrient, and investigated whether re-administration of nutrient recovers intestinal functions using nutrient non-influx model of rats. Our data suggested that inactivation of mTOR pathway and downregulation of cell cycle related genes such as cyclins are associated with villus atrophy in non-influx model animals. In addition, we demonstrated that almost genes related to digestion and absorption of nutrients significantly increased by re-administration of nutrient. Interestingly, we revealed that there was a different effect between each nutrient category such as carbohydrates, lipids and amino acids and further between each nutrient quality such as glucose, fructose, medium-chain triacylglycerol, long-chain triacylglycerol, glutamine and arginine.
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