| Project/Area Number |
23700910
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nagoya City University |
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Principal Investigator |
ZHAO Juan 名古屋市立大学, 医学(系)研究科(研究院), 助教 (20381890)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 大豆イソフラボン / 卵巣摘出 / 認知機能 / 更年期 |
|---|
| Research Abstract |
Soy-isoflavone has been utilized as phytoestrogens to prevention cognitive symptoms found in menopausal women because its biological activities similar to those of estrogens. However, the precise mechanisms underlying its effects remain unknown. In this study, effects of soy-isoflavone on spatial memory were investigated in ovariecomized (OVX) mice. Administration of isoflavone for 4 weeks to OVX mice increased hippocampal levels of IGF-I and prevented the decrease of spatial memory. Immunohistochemical expression of DCX and BrdU suggested an enhancement of neurogenesis in the dentate gyrus of the hippocampus after isoflavone administration. These observations suggest that isoflavone might promote spatial memory through increasing hippocampal IGF-I level and neurogenesis in OVX-mice.
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