| Project/Area Number |
23700917
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Okayama Prefectural University |
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Principal Investigator |
NAKATA Kazue 岡山県立大学, 保健福祉学部, 助教 (60411740)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 腸管マクロファージ / 腸管感染症 / 感染防御 / 組織特異性 / 腸管免疫機構 / 腸内細菌 |
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| Research Abstract |
The study aimed to clarify the mechanism of foreign substances recognition and elimination by intestinal macrophages and to identify selective intestinal macrophage responses, such as phagocytosis, bactericidal activity, and cytokine production, induced by nonpathogenic E. coli, V. parahaemolyticus, S. aureus, and L. casei. The phagocytosis of L. casei by intestinal macrophages was significantly lower than that of E. coli, V. parahaemolyticus, S. aureus. The bactericidal activities of intestinal macrophages differed for different bacterial species. TNF-alpha and IL-12 production induced by E. coli, V. parahaemolyticus, and S. aureus stimulation was significantly higher than that induced by LPS but not L. casei. IL-10 production was same for LPS and all bacteria. The production of TNF-alpha and IL-12 in intestinal macrophages may be related to phagocytosis. These results confirmed that intestinal macrophages show different responses to individual bacteria specie.
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