Effect of polyunsaturated fatty acids on neurogenesis of fetus and infancy.
| Project/Area Number |
23700929
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kinjo Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 必須脂肪酸 / 神経栄養因子 / 多価不飽和脂肪酸 / リン酸化シグナル / プロテインキナーゼ |
|---|
| Research Abstract |
Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), which are important factors in the neurogenesis, differentiation and maintenance. Postnatalmice were fed n-3 fatty acids restricted diet in two weeks. The cerebral cortex, striatum, hippocampus were collected from pups raised in breast milk of those parents. On fatty acid profile, docosahexaenoic acid (DHA) content was decreased in n-3 fatty acids restricted diet group. Arachidonic acid content was increased conversely. n-6/n-3 system ratio was significantly increased in n-3 fatty acid deficient diet group. Further, BDNF content was significantly altered between the dietary groups by the region, which produces different results depending on regions, it is important to further examine its details.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Development of novel rat model for high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis progression in SHRSP5/Dmcr2012
Author(s)
Kitamori K., Naito H., Tamada H., Kobayashi M., Miyazawa D., Yasui Y., Sonoda K., Tsuchikura S., Yasui N., Ikeda K., Moriya T., Yamori Y., Nakajima T.
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Journal Title
Environ. Health Prev. Med.
Volume: 17(3)
Pages: 173-182
NAID
Related Report
Peer Reviewed
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[Journal Article] Development of novel rat model for high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis progression in SHRSP5/Dmcr2012
Author(s)
Kitamori K, Naito H, Tamada H, Kobayashi M, Miyazawa D, Yasui Y, Sonoda K, Tsuchikura S, Yasui N, Ikeda K, Moriya T, Yamori Y, Nakajima T.
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Journal Title
Environmental Health and Preventive Medicine
Volume: 17
Pages: 173-182
NAID
Related Report
Peer Reviewed
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