| Project/Area Number |
23700932
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nagoya Women's University |
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Principal Investigator |
KONDO HIROYO 名古屋女子大学, 家政学部, 准教授 (50333183)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨格筋 / サルコペニア / 血管 / 糖尿病 / 栄養 / ロコモティブシンドローム |
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| Research Abstract |
Identification of nutrients with significant cross-talk between muscle and vessel potential useful for the development of preventive therapy in sarcopenia has gained increasing importance. Therefore, the aim of this study was investigated the cross-talk between muscle fiber and capillary potential of nutrients against myoblasts and pathological animal models. Several nutrients such as plant and animal food derived extracts showed high proliferation potency in myoblasts. In addition, these nutrients were administrated orally to the rats of muscle atrophy. As expected, the nutrients of dairy product extracts, antioxidants, and hyperamino acids attenuated the muscle atrophy and maintained the capillary networks, and oxdative stress levels. These results indicate that nutrients could be an effective therapy for both the muscle and capillary associated with a chronic decrease in neuromuscular activity and/or diabetes.
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