Effects of maternal nutrition for essential metals on placental leptin expression
| Project/Area Number |
23700933
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Eating habits, studies on eating habits
|
|---|
| Research Institution | Osaka Ohtani University |
|---|
Principal Investigator |
UEDA Hidenori 大阪大谷大学, 薬学部, 助教 (50419462)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 必須金属 / レプチン / 胎盤 / 妊娠 |
|---|
| Research Abstract |
Effects of maternal deficiency and overload of essential metals on placental leptin expression were studied in pregnant mice and human placental choriocarcinoma cell line JEG-3. The levels of plasma leptin and leptin receptor expression were decreased in essential metals deficient mice and increased in them overloaded mice. These results suggest that placenta-derived leptin and its receptor expression may be controlled by maternal nutrition of essential metals for fetal development.
|
Report
(3 results)
Research Products
(4 results)
