Effects of maternal nutrition for essential metals on placental leptin expression

Research Project

Project/Area Number	23700933
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Eating habits, studies on eating habits
Research Institution	Osaka Ohtani University
Principal Investigator	UEDA Hidenori 大阪大谷大学, 薬学部, 助教 (50419462)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	必須金属 / レプチン / 胎盤 / 妊娠
Research Abstract	Effects of maternal deficiency and overload of essential metals on placental leptin expression were studied in pregnant mice and human placental choriocarcinoma cell line JEG-3. The levels of plasma leptin and leptin receptor expression were decreased in essential metals deficient mice and increased in them overloaded mice. These results suggest that placenta-derived leptin and its receptor expression may be controlled by maternal nutrition of essential metals for fetal development.

Report

(3 results)