| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Research Abstract |
Obesity has been considered as a risk factor for cerebral stroke. Recently it has been clarified that too lean persons has more risk for stroke incidence than normal individuals do.
Malignant stroke-prone spontaneously hypertensive rats (M-SHRSP) develop spontaneous stroke at early age without obesity, therefore this strain serves as a model of cerebrovascular stroke without the metabolic syndrome. In this study, we investigated a new strategy to prevent cerebral lesions of a rat spontaneous stroke model with and without the obesity.
The prior treatment with a PPAR-alpha agonist prevented the onset of cerebral lesions in M-SHRSP. Additionally, the hypoadiponectinemia was observed in obese M-SHRSP fed a high-fat diet, however, both incidence and mortality of stroke were markedly prevented. Our results show that improvement in nutrition and lipid metabolism prevents the development of brain lesion in spontaneous stroke model without obesity.
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