| Project/Area Number |
23700937
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
AKAZAWA Yoko 独立行政法人産業技術総合研究所, 健康工学研究部門, 研究員 (50549897)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 健康と食生活 / 脂質酸化 / 細胞応答 / 酸化ストレス / 抗酸化システム / 炎症 / メタボリックシンドローム |
|---|
| Research Abstract |
We have studied the biological significance of lipid oxidation metabolites by performing cell line. They can exert adaptive response under oxidative stress while they may be yielded depending on the diseases. Lipid oxidation products, which can exert both deleterious and cytoprotective effects by modifying proteins and their function, are considered to be cellular regulatory factors. The oxidation of linoleate metabolites by singlet-oxygen leads to the formation of the HODE isomers. 10-EZ-HODE and 12-ZE-HODE induce antioxidants and the adaptive response to reduce oxidative damage.
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