Analysis of phospholipid metabolic enzymes in thyroid tumors

Research Project

Project/Area Number	23701036
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Carcinogenesis
Research Institution	Akita University
Principal Investigator	KOFUJI Satoshi 秋田大学, 大学院・医学系研究科, 教育系補佐員 (00508153)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	リン脂質 / 脂質 / 遺伝子改変動物
Research Abstract	Phosphatidylinositols are one of the important lipids composed of cell membranes, and there are eight species. Their abundance is very little, but they function as a signal molecule, and the dysfunction of the production or degradation of each species causes critical diseases, so they have been extensively researched. In this study, we analyzed the physiological roles by creating knockout mice for their enzymes. We found that the enzymes had an important role in thyroid tumors.