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Clinical application of TGF-beta signal in chronic hepatitis B

Research Project

Project/Area Number 23701039
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Carcinogenesis
Research InstitutionKansai Medical University

Principal Investigator

MURATA Miki  関西医科大学, 医学部, 助教 (10533416)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsSmad3リン酸化 / B型慢性肝炎 / TGF-β / Smad3 / 部位特異的リン酸化Smad単クローン抗体 / 肝発癌
Research Abstract

In our recent studies, HBV clearance at an early stage by anti viral therapy restored hepatocytic TGF-beta signaling from fibro carcinogenesis toward the tumor suppression. Moreover, low pSmad3C and high pSmad3L positivity were significantly predictive of human HCC development. We conclude that pSmad3L and pSmad3C can serve as a useful markers determining whether you can defend development of viral related HCC by antiviral therapy. Using an individua s phospho-Smad3 markers, clinicians may be able to achieve more effective chemoprevention and individualized therapy for HBV infected patients.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (16 results)

All 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (12 results) Book (2 results)

  • [Journal Article] B型慢性肝炎におけるTGF-βシグナル伝達2011

    • Author(s)
      村田美樹
    • Journal Title

      関西医科大学雑誌

      Volume: 62巻 Pages: 13-39

    • NAID

      130000666055

    • Related Report
      2013 Final Research Report
  • [Journal Article] B型慢性肝炎におけるTGF-βシグナル伝達2011

    • Author(s)
      村田 美樹
    • Journal Title

      関西医科大学雑誌

      Volume: 62 Pages: 13-39

    • NAID

      130000666055

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 癌化・線維化シグナルからみた抗ウイルス療法後のC型慢性肝疾患の病態について検討2013

    • Author(s)
      村田美樹
    • Organizer
      第40回日本肝臓学会西部会
    • Place of Presentation
      長良川国際会議場・岐阜都ホテル(岐阜)
    • Year and Date
      2013-12-06
    • Related Report
      2013 Final Research Report
  • [Presentation] B型慢性肝疾患における癌化・線維化シグナルの検討2013

    • Author(s)
      村田美樹
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      京王プラザ(東京)
    • Year and Date
      2013-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] B型慢性肝疾患における癌化、線維化シグナルの比較検討2013

    • Author(s)
      村田 美樹
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      京王プラザ (東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 癌化・線維化シグナルからみた抗ウイルス療法後のC型慢性肝疾患の病態についての2013

    • Author(s)
      村田 美樹
    • Organizer
      第40回日本肝臓学会西部会
    • Place of Presentation
      長良川国際会議場・岐阜都ホテル (岐阜)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Reversible or irreversible phospho-Smad2/3 signaling2012

    • Author(s)
      Miki Murata
    • Organizer
      TGF-βシグナル国際シンポジウム
    • Place of Presentation
      昭和薬科大学(東京)
    • Year and Date
      2012-10-29
    • Related Report
      2013 Final Research Report
  • [Presentation] B型慢性肝炎における TGF-βシグナル伝達機構の臨床応用2012

    • Author(s)
      村田美樹
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      全日空ホテル(金沢)
    • Year and Date
      2012-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] B型慢性肝炎におけるTGF-βシグナル伝達機構の臨床応用2012

    • Author(s)
      村田 美樹
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      全日空ホテル 金沢
    • Related Report
      2012 Research-status Report
  • [Presentation] Reversible or irreversible phospho-Smad2/3 signaling2012

    • Author(s)
      村田 美樹
    • Organizer
      TGF-βシグナル国際シンポジウム
    • Place of Presentation
      昭和薬科大学 東京
    • Related Report
      2012 Research-status Report
  • [Presentation] B型、C型慢性肝疾患における抗ウイルス療法後の癌化、線維化シグナルの検討2011

    • Author(s)
      村田美樹
    • Organizer
      第39回日本肝臓学会西部会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Year and Date
      2011-12-09
    • Related Report
      2013 Final Research Report
  • [Presentation] B型慢性肝疾患の線維化・癌化シグナルは、核酸アナログ治療後、癌抑制シグナルに回帰する2011

    • Author(s)
      村田美樹
    • Organizer
      第47回日本肝癌研究会
    • Place of Presentation
      静岡コンベンションアーツセンター(静岡)
    • Year and Date
      2011-07-28
    • Related Report
      2013 Final Research Report
  • [Presentation] B型慢性肝疾患の線維化・癌化シグナルは、核酸アナログ治療後、癌抑制シグナルに回帰する2011

    • Author(s)
      村田 美樹
    • Organizer
      第47回日本肝癌研究会
    • Place of Presentation
      静岡コンベンションアーツセンター
    • Related Report
      2011 Research-status Report
  • [Presentation] B型、C型慢性肝疾患における抗ウイルス療法後の癌化、線維化シグナルの検討2011

    • Author(s)
      村田 美樹
    • Organizer
      第39回日本肝臓学会西部会
    • Place of Presentation
      岡山コンベンションセンター
    • Related Report
      2011 Research-status Report
  • [Book] Early chronic inflammation and subsequent somatic mutations shift phospho-Smad3 signaling from tumor-suppression to fibro-carcinogenesis in human chronic liver diseases. In: Ahmed O. Kaseb (ed). Hepatocellular carcinoma-future outlook2013

    • Author(s)
      Miki Murata, Katsunori Yoshida, Koichi Matsuzaki
    • Publisher
      In Tech, Croatia
    • URL

      http://dx.doi.org/10.5772/56739

    • Related Report
      2013 Final Research Report
  • [Book] Early chronic inflammation and subsequent somatic mutations shift phospho-Smad3 signaling from tumor- suppression to fibro-carcinogenesis in human chronic liver diseases.2013

    • Author(s)
      Miki Murata, Katsunori Yoshida, Koichi Matsuzaki.
    • Total Pages
      30
    • Publisher
      InTech
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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