Research Project
Grant-in-Aid for Young Scientists (B)
Using a bioluminescence imaging system for p16^<INK4a> expression in living mice, we show that oncogenic insults such as obesity and p53 inactivation provoke de-repression of p16INK4a expression in progenitors of adipose tissue. p53 inactivation increases DNA damage and reactive oxygen species(ROS) in progenitors of adipose tissues, indicating that obesity generates oncogenic stress in these cells.
All 2013 2012 2011 2010 Other
All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results) Book (4 results) Remarks (1 results)
Molecular Cell
Volume: 45(1) Pages: 123-131
Inflammation and Regeneration
Volume: 32(1) Pages: 32-38
130004482290
Volume: 32 Issue: 1 Pages: 032-038
10.2492/inflammregen.32.032
http://www.ncgg.go.jp/department/dma/biochemistry_ky_.html