| Project/Area Number |
23701043
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Yamagata University |
|---|
Principal Investigator |
MIKA Kaneko 山形大学, 医学部, 講師 (00323163)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ポドプラニン / PDPN / 腫瘍特異的糖鎖構造 / 糖転移酵素遺伝子 / miRNA / 糖転移酵素 / non-coding RNA / 癌幹細胞マーカー |
|---|
| Research Abstract |
Podoplanin (PDPN) is a mucin-type sialoglycoprotein associatedwith tumor metastasis, malignant progression, and cancer stem cells. Recently, werevealed the existence of tumor specific glycan on PDPN. In this study, we showed thatseveral glycosyltransferase genes are involved in the tumor specific glycan on PDPN.Furthermore, we investigated the potential role of noncoding RNA such as microRNAs inglycosyltransferase gene regulation.
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