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Undifferentiated state induced by Rb inactivation associated with activation of inflammatory signaling

Research Project

Project/Area Number 23701048
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor biology
Research InstitutionKanazawa University

Principal Investigator

KITAJIMA Shunsuke  金沢大学, がん進展制御研究所, 博士研究員 (90566465)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
KeywordsRb / p53 / Cancer stem cell / Inflammation / Trp53
Research Abstract

Inactivation of Rb is frequently found during tumor progression. We found that Rb inactivation in p53 null background contributes to the acquisition of cancer stemness. RNA sequence analysis revealed that these cells exhibited signatures of inflammatory conditions. Knockdown experiments showed that sphere-forming activity induced by Rb depletion depend on activation of IL6 -STAT3 axis. Moreover, it seems that activation of STAT3 pathway induced by Rb inactivation directly cause an inflammatory tumor environment. These results are expected to provide some new insights into cell autonomous and non-cell autonomous function of Rb during tumor progression.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (20 results)

All 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (17 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Twists in views on RB functions in cellular signaling, metabolism and stem cells.2012

    • Author(s)
      Chiaki Takahashi
    • Journal Title

      Cancer Science

      Volume: Volume103, Issue7 Issue: 7 Pages: 1182-1188

    • DOI

      10.1111/j.1349-7006.2012.02284.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rb/E2F1 regulates the innate immune receptor Toll-like receptor 3 in epithelial cells2012

    • Author(s)
      Taura M., et.al.
    • Journal Title

      Molecular and Cellular Biology

      Volume: 32(8) Issue: 8 Pages: 1581-1590

    • DOI

      10.1128/mcb.06454-11

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Undifferentiated state induced by Rb inactivation associated with metabolic reprogramming and inflammation2013

    • Author(s)
      北嶋俊輔,高橋智聡
    • Organizer
      平成24年度個体レベルでのがん研究支援活動ワークショップ
    • Place of Presentation
      琵琶湖ホテル(滋賀県)
    • Year and Date
      2013-02-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Undifferentiated state induced by Rb inactivation associated with metabolic reprogramming and inflammation2013

    • Author(s)
      Kitajima,S.,Takahashi,C.
    • Organizer
      9thAACR/JCA Joint Conference
    • Place of Presentation
      Hyatt Regency Maui (USA)
    • Year and Date
      2013-02-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Undifferentiatedstate induced by Rb inactivation associated with metabolic reprogramming and inflammation2013

    • Author(s)
      北嶋俊輔,高橋智聡
    • Organizer
      平成24年度がん研究分野の特性等を踏まえた支援活動公開シンポジウム
    • Place of Presentation
      学術総合センター一橋講堂(東京都)
    • Year and Date
      2013-01-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Undifferentiated state induced by Rb inactivation associated with metabolic reprogramming and inflammation2013

    • Author(s)
      Kitajima,S.,Takahashi,C.
    • Organizer
      The 3rd International Symposium on Carcinogenic Spiral and Internatinal Symposium on Tumor Biology in Kanazawa
    • Place of Presentation
      金沢エクセルホテル東急 (石川県)
    • Year and Date
      2013-01-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Undifferentiated state induced by Rb inactivation associated with metabolic reprogramming and inflammation2012

    • Author(s)
      北嶋俊輔,高橋智聡
    • Organizer
      35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Undifferentiated cancer stem cell-like phenotypes induced by Rb-p53 inactivation2012

    • Author(s)
      北嶋俊輔,高橋智聡
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Undifferentiated cancer stem cell-like phenotypes induced by Rb-p53 inactivation2012

    • Author(s)
      Kitajima,S.,Takahashi,C.
    • Organizer
      The 7th International Symposium of the Institute Network
    • Place of Presentation
      東北大学加齢医学研究所(宮城県)
    • Year and Date
      2012-06-14
    • Related Report
      2012 Final Research Report
  • [Presentation] The RB-SREBP nexus where RB meets cell signaling and lipid metabolism.2012

    • Author(s)
      S.Kitajima, Y.Kido, H.Muranaka, N.Sasaki, S.Kohno, C.Takahashi
    • Organizer
      Keystone Symposia -Cancer and Metabolism-
    • Place of Presentation
      Fairmont Banff Springs (Canada)
    • Related Report
      2011 Research-status Report
  • [Presentation] The Rb-lipid signaling axis revealed by Rb composite knockout mouse studies.2011

    • Author(s)
      S.Kitajima, Y.Kido, H.Muranaka, N.Sasaki, S.Kohno, C.Takahashi.
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜 (神奈川)
    • Related Report
      2011 Research-status Report
  • [Presentation] The RB-SREBP nexus where RB meets cell signaling and lipid metabolism.2011

    • Author(s)
      S.Kitajima, C.Takahashi
    • Organizer
      Second International Rb Meeting
    • Place of Presentation
      Chestnut Conference Centre (Canada)
    • Related Report
      2011 Research-status Report
  • [Presentation] Undifferentiated state induced by Rb inactivation associated with metabolic reprogramming and inflammation

    • Author(s)
      Shunsuke Kitajima
    • Organizer
      9th AACR/JCA Joint Conference
    • Place of Presentation
      Hyatt Regency Maui (USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Undifferentiated state induced by Rb inactivation associated with metabolic reprogramming and inflammation

    • Author(s)
      Shunsuke Kitajima
    • Organizer
      平成24年度個体レベルでのがん研究支援活動ワークショップ
    • Place of Presentation
      琵琶湖ホテル
    • Related Report
      2012 Annual Research Report
  • [Presentation] Undifferentiated state induced by Rb inactivation associated with metabolic reprogramming and inflammation

    • Author(s)
      Shunsuke Kitajima
    • Organizer
      平成24年度がん研究分野の特性等を踏まえた支援活動公開シンポジウム
    • Place of Presentation
      学術総合センター一橋講堂
    • Related Report
      2012 Annual Research Report
  • [Presentation] Undifferentiated state induced by Rb inactivation associated with metabolic reprogramming and inflammation

    • Author(s)
      Shunsuke Kitajima
    • Organizer
      The 3rd International Symposium on Carcinogenic Spiral and Internatinal Symposium on Tumor Biology in Kanazawa
    • Place of Presentation
      金沢エクセルホテル東急
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Undifferentiated state induced by Rb inactivation associated with metabolic reprogramming and inflammation

    • Author(s)
      Shunsuke Kitajima
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Undifferentiated cancer stem cell-like phenotypes induced by Rb-p53 inactivation

    • Author(s)
      Shunsuke Kitajima
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] Undifferentiated cancer stem cell-like phenotypes induced by Rb-p53 inactivation

    • Author(s)
      Shunsuke Kitajima
    • Organizer
      The 7th International Symposium of the Institute Network
    • Place of Presentation
      東北大学加齢医学研究所
    • Related Report
      2012 Annual Research Report
  • [Book] 「インビトロ幹細胞モデル」『実験医学増刊 がん幹細胞 ―ステムネス、ニッチ、標的細胞への理解―』2011

    • Author(s)
      北嶋俊輔、高橋智聡
    • Total Pages
      7
    • Publisher
      羊土社
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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