Research Project
Grant-in-Aid for Young Scientists (B)
Inactivation of Rb is frequently found during tumor progression. We found that Rb inactivation in p53 null background contributes to the acquisition of cancer stemness. RNA sequence analysis revealed that these cells exhibited signatures of inflammatory conditions. Knockdown experiments showed that sphere-forming activity induced by Rb depletion depend on activation of IL6 -STAT3 axis. Moreover, it seems that activation of STAT3 pathway induced by Rb inactivation directly cause an inflammatory tumor environment. These results are expected to provide some new insights into cell autonomous and non-cell autonomous function of Rb during tumor progression.
All 2013 2012 2011 Other
All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (17 results) (of which Invited: 1 results) Book (1 results)
Cancer Science
Volume: Volume103, Issue7 Issue: 7 Pages: 1182-1188
10.1111/j.1349-7006.2012.02284.x
Molecular and Cellular Biology
Volume: 32(8) Issue: 8 Pages: 1581-1590
10.1128/mcb.06454-11
