microRNA-125b inhibits tumor vascular formation through translational suppression of VE-cadherin
Project/Area Number |
23701054
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Tumor biology
|
Research Institution | Osaka University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | マイクロRNA / 血管新生 / 細胞接着 / 癌治療 / 核酸医薬 / 腫瘍血管新生 / 癌研究 / miRNA |
Research Abstract |
MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that function as negative regulators of gene expression. Posttranscriptional regulation by miRNAs is important for many aspects of development and disease. Sveral miRNAs are highly expressed in endothelial cells. Whereas the specific functions of miRNAs for tumor angiogenesis are less clear. Here, we identified miRNAs that were enriched in endothelial cells derived from LLC tumor. We found that miR-125b regulated the expression of endothelial cell adherent protein VE-cadherin. Additionally, overexpression of miR-125b in endothelial cells resulted in inhibition of proliferation, tube formation and migration activity. Furthermore, in vivo transfection of mir-125b in subcutaneous implanted LLC tumor, inhibited neo vascular formation and suppressed tumor growth. These findings illustrate that mir-125b act as negative regulator of tumor angiogenesis and providing a new target for modulating vascular formation and function.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Critical role of Trib1 for the differentiation of adipose tissue-resident macrophages maintaining metabolic homeostasis.2013
Author(s)
Satoh T, Kidoya H, Naito H, Yamamoto M, Takemura N, Nakagawa K, Yoshioka Y, Morii E, Takakura N, Takeuchi O, Akira S
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Journal Title
Nature
Volume: 495(7442)
Issue: 7442
Pages: 524-528
DOI
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Peer Reviewed
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[Journal Article] The transcription factor Jun dimerization protein 2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation2012
Author(s)
kenta Maruyama, Masahiro Fukasaka, Alexis Vandenbon, Tatsuya Saitoh, Takumi Kawasaki, Takeshi Kondo, Kazunari K. Yokoyama, Hiroyasu Kidoya, Nobuyuki Takakura, Daron Standley, Osamu Takeuchi, and Shizuo Akira
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Journal Title
Immunity
Volume: 37
Issue: 6
Pages: 1024-1036
DOI
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Peer Reviewed
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[Book] 血管医学2013
Author(s)
村松史隆,木戸屋浩康,高倉伸幸
Total Pages
14
Publisher
メディカルレビュー社
Related Report
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