• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Toward understanding of the lipid raft-based Src regulatory system

Research Project

Project/Area Number 23701056
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor biology
Research InstitutionOsaka University

Principal Investigator

KAJIWARA Kentaro  大阪大学, 微生物病研究所, 特任研究員 (30581102)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsがん化 / Src / 脂質ラフト / スフィンゴ脂質 / シグナル伝達 / 発がん
Research Abstract

The proto-oncogene product c-Src is highly upregulated in various cancer cells. Src function is downregulated in the lipid rafts, indicating the lipid rafts serve as a negative regulator of activated c-Src. However, it has not been known how lipid rafts are altered during c-Src-induced cancer progression. In this study, we newly revealed that raft-localization of c-Src is regulated by lipid metabolism and that inhibition of lipid alteration suppresses c-Src-induced cell transformation. Taken together, Src regulates raft integrity by alteration of lipid metabolism for maintaining c-Src activation.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2013 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (12 results)

  • [Journal Article] Perturbation of sphingolipid metabolism induces endoplasmic reticulum stress-mediated mitochondrial apoptosis in budding yeast2012

    • Author(s)
      Kentaro Kajiwara
    • Journal Title

      Molecular Microbiology

      Volume: 86 Issue: 5 Pages: 1246-1261

    • DOI

      10.1111/mmi.12056

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Src活性化に伴うセラミドの増加はがん形質発現を促進する2013

    • Author(s)
      梶原健太郎、小根山千歳、岡田雅人
    • Organizer
      がん研究分野の特性等を踏まえた支援活動 公開シンポジウム
    • Place of Presentation
      学術総合センター
    • Year and Date
      2013-01-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Src活性化に伴うセラミドの増加はがん形質発現を促進する2013

    • Author(s)
      梶原 健太郎
    • Organizer
      がん研究分野の特性等を踏まえた支援活動 公開シンポジウム
    • Place of Presentation
      学術総合センター(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] スフィンゴミエリン分解酵素nSMase2によるがん形質発現制御機構の解析2012

    • Author(s)
      安藤雄哉、梶原健太郎、小根山千歳、岡田雅人
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2012-12-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Metabolic alteration of lipid components in membrane microdomain by c-Src-induced transformation2012

    • Author(s)
      梶原健太郎、小根山千歳、今本文男、岡田雅人
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2012-12-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Src活性化に伴うセラミドの増加はがん形質発現を促進する(口頭発表)2012

    • Author(s)
      梶原健太郎、小根山千歳、今本文男、岡田雅人
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Src活性化に伴うセラミドの増加はがん形質発現を促進する(ポスター発表)2012

    • Author(s)
      梶原健太郎、小根山千歳、今本文男、岡田雅人
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Alteration of ceramide metabolism is required for c-Src redistribution to focal adhesions and following activation of signal transduction pathways during cell transformation2012

    • Author(s)
      Kentaro Kajiwara, Chitose Oneyama, Masato Okada
    • Organizer
      The 4th EMBO meeting
    • Place of Presentation
      Nice Acropolis (France)
    • Year and Date
      2012-09-24
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Metabolic alteration of raft lipids by c-Src expression2012

    • Author(s)
      梶原健太郎、小根山千歳、今本文男、岡田雅人
    • Organizer
      平成23年度がん若手研究者ワークショップ
    • Place of Presentation
      アートランドホテル蓼科
    • Year and Date
      2012-09-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Src活性化に伴うセラミドの増加はがん形質発現を促進する2012

    • Author(s)
      梶原 健太郎
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Metabolic alteration of raft lipids by c-Src expression2011

    • Author(s)
      梶原健太郎
    • Organizer
      平成23年度がん若手研究者ワークショップ
    • Place of Presentation
      アートランドホテル蓼科(長野県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Metabolic alteration of lipid components in membrane microdomain by c-Src-induced transformation2011

    • Author(s)
      梶原健太郎
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] スフィンゴミエリン分解酵素nSMase2によるがん形質発現制御機構の解析2011

    • Author(s)
      安藤雄哉
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi