NDRG2 inactivation and PI3K/Akt pathway activation in cancers
Project/Area Number |
23701061
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Tumor biology
|
Research Institution | University of Miyazaki |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | NDRG2 / PTEN / PI3K/Akt / がん / PI3K/AKT |
Research Abstract |
This study showed that PTEN is highly phosphorylated in a varietyof cancers and restoring expression of NDRG2 suppresses phosphorylation of PTEN and Akt.We also demonstrate for the first time that NDRG2 acts as a tumor suppressor. These resultscould contribute to the development of new drug targeting PTEN phosphorylation anddephosphorylation.
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Report
(3 results)
Research Products
(11 results)