| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Research Abstract |
Solid tumors have regions of hypoxia and glucose deprivation, in which cancer cells activate the unfolded protein response (UPR). The UPR in cancer cells plays an important role in their survival under stress conditions, and thus the UPR is a potential target of antitumor therapy. Several UPR inhibitors are shown to exert antitumor activity in vivo. However, the effect of the UPR inhibitors on tumor microenvironment is not fully understood. We show that the UPR inhibitors suppress the gene expression both in cancer cells and in macrophages under hypoxic conditions.
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