Functional analysis of phosphoinositides in invasion and metastasis of breast cancer cells
| Project/Area Number |
23701069
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
YAMAGUCHI Hideki 独立行政法人国立がん研究センター, 研究所, ユニット長 (10345035)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 浸潤 / 癌 / 浸潤突起 / イノシトールリン脂質 |
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| Research Abstract |
Invadopodia are membrane protrusions formed by invasive cancer cells that mediate degradation of pericellular ECM and have been implicated in local invasion during cancer metastasis. In this study, we investigated the role of phosphoinositide metabolism in invadopodium formation. We found that PI3 kinase p110α, a frequently mutated gene product in human cancers, is involved in invadopodium formation and invasion by breast cancer cells. This finding suggests that the signaling pathway via p110α is a potential therapeutic target for the treatment of cancer invasion and metastasis.
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Report
(3 results)
Research Products
(33 results)
