• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis for crosstalk between estrogen and Wnt signalings

Research Project

Project/Area Number 23701070
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor biology
Research Institution大学共同利用機関法人自然科学研究機構(岡崎共通研究施設) (2012)
National Institutes of Natural Sciences Okazaki Research Facilities (2011)

Principal Investigator

MIYAGAWA Shinichi  大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 助教 (30404354)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords女性ホルモン / Wnt / 女性生殖器官 / 女性生殖器
Research Abstract

An integrated network of endocrine chemicals (hormones) modulates the reproductive systems in most animals. Estrogens, one class of these endocrine hormones, are responsible for the induction of behavioral and physiological processes involving many organ systems. The female reproductive tract provides the sites for gamete fertilization, implantation and subsequent development of the embryo and delivery of the fetus. Organs in the female reproductive tract are also involved in women’s health issues including and tumorigenesis. Growth factors and ER signaling cooperate to play essential roles in cell proliferation, differentiation and tumor progression in mouse reproductive organs. Treatment of neonatal mice with diethylstilbestrol (DES) induces an estrogen-independent persistent proliferation and cornification of the vaginal epithelium, which typically results in cancerous lesions later in life. However, the mechanisms of the estrogen-dependent and -independent pathways had remained essentially unknown. We found that Wnt/beta-catenin signaling is involved in estrogen-independent phenomena in mouse vagina developmentally exposed to estrogens.。

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2012 2011 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (2 results) Remarks (2 results)

  • [Journal Article] Sequential changes in the expression of Wnt- and Notch-related genes in the vagina and uterus of ovariectomized mice after estrogen exposure2012

    • Author(s)
      Nakamura T, Miyagawa S, Katsu Y, Sato T, Iguchi T, Ohta Y
    • Journal Title

      In Vivo

      Volume: 26 Pages: 899-906

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] P21 and Notch signalings in the persistently altered vagina induced by neonatal diethylstilbestrol exposure in mice2012

    • Author(s)
      Nakamura T, Miyagawa S, Katsu Y, Mizutani T, Sato T, Takeuchi T, Iguchi T, Ohta Y
    • Journal Title

      J Vet Med Sci

      Volume: 74 Pages: 1589-1595

    • NAID

      130001879705

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] WNT family genes and their modulation in the ovary-independent and persistent vaginal epithelial cell proliferation and keratinization induced by neonatal diethylstilbestrol exposure in mice2012

    • Author(s)
      Nakamura T, Miyagawa S, Katsu Y, Watanabe H, Mizutani T, Sato T, Morohashi KI, Takeuchi T, Iguchi T, Ohta Y
    • Journal Title

      Toxicology

      Volume: 296 Pages: 13-19

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] p21 and Notch signalings in the persistently altered vagina induced by neonatal diethylstilbestrol exposure in mice2012

    • Author(s)
      Nakamura et al.
    • Journal Title

      J Vet Med Sci

      Volume: 74 Pages: 1589-1595

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wnt family genes and their modulation in the ovary-independent and persistent vaginal epithelial cell proliferation and keratinization induced by neonatal diethylstilbestrol exposure in mice.2012

    • Author(s)
      Nakamura T, Miyagawa S, Katsu Y, Watanabe H, Mizutani T, Sato T, Morohashi KI, Takeuchi T, Iguchi T, Ohta Y
    • Journal Title

      Toxicology

      Volume: 296 Issue: 1-3 Pages: 13-19

    • DOI

      10.1016/j.tox.2012.02.010

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of sonic hedgehog-gli2 pathway in the masculinization of external genitalia2011

    • Author(s)
      Miyagawa S, Matsumaru D, Murashima A, Omori A, Satoh Y, Haraguchi R, Motoyama J, Iguchi T, Nakagata N, Hui CC, Yamada G
    • Journal Title

      Endocrinology

      Volume: 152 Pages: 2894-2903

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms of induction of persistent changes by estrogenic chemicals on female reproductive tracts and external genitalia2011

    • Author(s)
      Miyagawa S, Sato M, Iguchi T
    • Journal Title

      J Steroid Biochem Mol Biol

      Volume: 127 Pages: 51-57

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Essential functions of androgen signaling emerged through the developmental analysis of vertebrate sex characteristics2011

    • Author(s)
      Ogino Y, Miyagawa S, Katoh H, Prins GS, Iguchi T, Yamada G
    • Journal Title

      Evol Dev

      Volume: 13 Pages: 315-325

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms of induction of persistent ch2011

    • Author(s)
      Miyagawa, S. et al.
    • Journal Title

      J Steroid Biochem Mol Biol.

      Volume: 127 Pages: 51-57

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The role of sonic hedgehog-gli2 pathway in the mas2011

    • Author(s)
      Miyagawa, S. et al.
    • Journal Title

      Endocrinology

      Volume: 152 Pages: 2894-2903

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Essential functions of androgen signaling emerged2011

    • Author(s)
      Ogino, Y., Miyagawa, S. et al.
    • Journal Title

      Evo Dev

      Volume: 13 Pages: 315-325

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Indispensable roles of estrogen receptor a for persistent vaginal change induced by neonatal 5a-dihydrotestosterone exposure2012

    • Author(s)
      Miyagawa S., Ohta Y., Iguchi T
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      ウェストドーバー、バーモント州、アメリカ
    • Year and Date
      2012-06-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Indispensable roles of estrogen receptor α for persistent vaginal change induced by neonatal 5α-dihydrotestosterone exposure2012

    • Author(s)
      Miyagawa er al.
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Mount Snow Resort (アメリカバーモント州)
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.nibb.ac.jp/%7Ebioenv1/index-j.html

    • Related Report
      2012 Final Research Report
  • [Remarks] Iguchi Lab on Web

    • URL

      http://www.nibb.ac.jp/%7Ebioenv1/index-j.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi