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Investigation for NK cell subset homeostasis and function in tumor mocroenvironment

Research Project

Project/Area Number 23701073
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor immunology
Research InstitutionUniversity of Toyama (2012)
The University of Tokyo (2011)

Principal Investigator

HAYAKAWA Yoshihiro  富山大学, 和漢医薬学総合研究所, 准教授 (10541956)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsNK細胞 / がん / がん転移
Research Abstract

CD27hi NK subset was the major population within tumor-infiltrating NK cells to be an early source of IFN-γ. Endogenous IFN-g was critical for NK cell recruitment into the tumor site and further critical effector molecule for anti-metastatic activity of NK cells. TRAIL, the effector molecule of NK cells, contrary played pro-metastatic role by providing inflammatory signal into tumor cells.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (24 results)

All 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (17 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Functional roles of tumor necrosis factor-related apoptosis-inducing ligand-DR5 interaction in B16F10 cells by activating the nuclear factor-KB pathway to induce metastatic potential2013

    • Author(s)
      Kei Takahashi, Kazuyoshi Takeda, Ikuo Saiki, Tatsuro Irimura and Yoshihiro Hayakawa
    • Journal Title

      Cancer Science

      Volume: 104 Issue: 5 Pages: 558-562

    • DOI

      10.1111/cas.12112

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of plant extracts sensitizing breast cancer cells to TRAIL.2013

    • Author(s)
      Abdelhamed S, Yokoyama S, Hafiyani L, Kalauni SK, Hayakawa Y, Awale S, Saiki I.
    • Journal Title

      Oncology Reports

      Volume: 29 Issue: 5 Pages: 1991-1998

    • DOI

      10.3892/or.2013.2293

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting NKG2D in tumor surveillance.2012

    • Author(s)
      Hayakawa Y.
    • Journal Title

      Expert Opinon on Therapeutic Targets

      Volume: 16 Issue: 6 Pages: 587-599

    • DOI

      10.1517/14728222.2012.681378

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Asialoglycoprotein Receptor Promotes Cancer Metastasis by Activating the EGFR-ERK Pathway.2011

    • Author(s)
      Ueno S, Mojic M, Ohashi Y, Higashi N , Hayakawa Y*, Irimura T*.
    • Journal Title

      Cancer Res

      Volume: 71(20) Issue: 20 Pages: 6419-27

    • DOI

      10.1158/0008-5472.can-11-1773

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early activation and interferon-Y production of tumor-infiltrating mature CD27 high natural killer cells2011

    • Author(s)
      Y.Hayakawa
    • Journal Title

      Cancer Sci

      Volume: 102 Issue: 11 Pages: 1967-1971

    • DOI

      10.1111/j.1349-7006.2011.02042.x

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] IFN-γ production by lung NK cells is sritical for the natural resistance to pulumonary metastasis of B16 melanoma in mice2011

    • Author(s)
      Takeda, K., Nakayama, M., et al
    • Journal Title

      J.Leukoc.Biol.

      Volume: 90 Issue: 4 Pages: 777-785

    • DOI

      10.1189/jlb.0411208

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Cancer immuneescalation process and the role of inflammatory tumor microenvironment for promoting metastasis2013

    • Author(s)
      Yoshihiro Hayakawa
    • Organizer
      Ninth AACR-JCR Joint Conference
    • Place of Presentation
      Maui, HI, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Cancer immuneescalation process and the role of inflammatory tumor microenvironment for promoting metastasis2012

    • Author(s)
      Yoshihiro Hayakawa
    • Organizer
      The 14th International Biennial Congress of the Metastasis Research Society
    • Place of Presentation
      Brisbane Convention & Exhibition Centre, Brisbane, Australia
    • Related Report
      2012 Final Research Report
  • [Presentation] ナチュラルキラー細胞の多様性とがん免疫応答における役割2012

    • Author(s)
      早川 芳弘
    • Organizer
      第21回日本がん転移学会学術集会・総会
    • Place of Presentation
      オリエンタルホテル広島、広島
    • Related Report
      2012 Final Research Report
  • [Presentation] 生物発光イメージングによるマウス4T1細胞の転移性微小環境における炎症性シグナル活性化の時空間的解析2012

    • Author(s)
      高橋 恵生、入村 達郎、早川 芳弘
    • Organizer
      第21回日本がん転移学会学術集会・総会
    • Place of Presentation
      広島
    • Related Report
      2012 Annual Research Report
  • [Presentation] ナチュラルキラー細胞の多様性とがん免疫応答における役割2012

    • Author(s)
      早川 芳弘
    • Organizer
      第21回日本がん転移学会学術集会・総会
    • Place of Presentation
      広島
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] IL-17-producing NK1.1+ CD27- γδT cells promote tumor malignant progression by inducing inflammatory microenvironment2012

    • Author(s)
      Yoshihiro Hayakawa, Yoshitaka Kimura, Naoki Tsunekawa, Marimo Sato-Matsushita, Hideaki Tahara, Ikuo Saiki, Tatsuro Irimura
    • Organizer
      第16回日本がん免疫学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cancer immune-escalation process and the role of inflammatory tumor microenvironment for promoting metastasis2012

    • Author(s)
      Yoshihiro Hayakawa
    • Organizer
      The 14th International Biennial Congress of the Metastasis Research Society
    • Place of Presentation
      Brisbane
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] IL-17-producing NK1.1+CD27- γδT cells promote tumor malignant progression by inducing inflammatory microenvironment2012

    • Author(s)
      早川 芳弘、佐藤(松下) まりも、田原 秀晃、済木 育夫、入村 達郎
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] がん免疫悪性化プロセスにおける炎症性サイトカインの役割2012

    • Author(s)
      早川芳弘
    • Organizer
      平成23年度個体レベルでのがん研究支援活動ワークショップ
    • Place of Presentation
      大津
    • Related Report
      2011 Research-status Report
  • [Presentation] Evidences for cancer immune-escalation process andthe role of inflammatory cytokines2011

    • Author(s)
      Yoshihiro Hayakawa
    • Organizer
      The 16th Korea-Japan Cancer Research Workshop
    • Place of Presentation
      札幌
    • Year and Date
      2011-12-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Cancer progression driven by microenvironment: role of cytokines revealed by novel in vivo model2011

    • Author(s)
      Yoshihiro Hayakawa
    • Organizer
      The Joint International Meeting of the 76th Conference of Japanese Society of Interferon and Cytokine Research and the 19th International Symposium of Macrophage Molecular and Cell Biology 2011
    • Place of Presentation
      大阪
    • Year and Date
      2011-05-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Cancer progression driven by microenvironment: role of cytokines revealed by novel in vivo model2011

    • Author(s)
      Yoshihiro Hayakawa
    • Organizer
      The Joint International Meeting of the 76th Conference of Japanese Society of Interferon and Cytokine Research and the 19th International Symposium of Macrophage Molecular and Cell Biology 2011(招待講演)
    • Place of Presentation
      大阪
    • Related Report
      2011 Research-status Report
  • [Presentation] がん免疫悪性化プロセスにおける炎症性サイトカインの役割2011

    • Author(s)
      早川芳弘
    • Organizer
      日本がん転移学会総会
    • Place of Presentation
      浜松
    • Related Report
      2011 Research-status Report
  • [Presentation] 腫瘍微小環境へのNK細胞集積におけるIFN-γの重要性2011

    • Author(s)
      早川芳弘
    • Organizer
      「がん研究分野の特性等を踏まえた支援活動」平成23年度 がん若手研究者ワークショップ
    • Place of Presentation
      蓼科
    • Related Report
      2011 Research-status Report
  • [Presentation] sialoglycoprotein receptor promotes cancer metastasis by activating EGFR-ERK pathway2011

    • Author(s)
      Yoshihiro Hayakawa
    • Organizer
      日本癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] がん免疫悪性化プロセスにおける炎症性サイトカインの役割2011

    • Author(s)
      早川芳弘
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      千葉
    • Related Report
      2011 Research-status Report
  • [Presentation] Evidences for cancer immune-escalation process and the role of inflammatory cytokines2011

    • Author(s)
      Yoshihiro Hayakawa
    • Organizer
      The 16th Korea-Japan Cancer Research Workshop(招待講演)
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.inm.u-toyama.ac.jp/pb/indexj.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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