Investigation for NK cell subset homeostasis and function in tumor mocroenvironment
Project/Area Number |
23701073
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Tumor immunology
|
Research Institution | University of Toyama (2012) The University of Tokyo (2011) |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | NK細胞 / がん / がん転移 |
Research Abstract |
CD27hi NK subset was the major population within tumor-infiltrating NK cells to be an early source of IFN-γ. Endogenous IFN-g was critical for NK cell recruitment into the tumor site and further critical effector molecule for anti-metastatic activity of NK cells. TRAIL, the effector molecule of NK cells, contrary played pro-metastatic role by providing inflammatory signal into tumor cells.
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Report
(3 results)
Research Products
(24 results)