| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
An adjuvant receptor ligand, poly(I:C), is a well-known ligand for both an endosomal receptor TLR3 and a cytoplasmic receptor MDA-5, and can augment immune responses. Cancer cell death accompanying autophagy was induced in human prostate cancer cell line after poly(I:C) treatment. Poly (I:C) transfection into cytoplasminduced autophagy concurrently with apoptosis in human breast cancer cell lines. Blocking of autophagy significantly promoted cancer cell death after poly(I:C) transfection. These results indicate that autophagy plays a cytoprotective role in cell death of human prostate and breast cancer cells when treated with poly(I:C).
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