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Cancer cell death and autophagy induced by the signaling of immune adjuvant receptors

Research Project

Project/Area Number 23701074
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor immunology
Research InstitutionShimane University

Principal Investigator

HARASHIMA Nanae  島根大学, 医学部, 助教 (60345311)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords癌 / 免疫 / シグナル伝達 / アポトーシス / オートファジー
Research Abstract

An adjuvant receptor ligand, poly(I:C), is a well-known ligand for both an endosomal receptor TLR3 and a cytoplasmic receptor MDA-5, and can augment immune responses. Cancer cell death accompanying autophagy was induced in human prostate cancer cell line after poly(I:C) treatment. Poly (I:C) transfection into cytoplasminduced autophagy concurrently with apoptosis in human breast cancer cell lines. Blocking of autophagy significantly promoted cancer cell death after poly(I:C) transfection. These results indicate that autophagy plays a cytoprotective role in cell death of human prostate and breast cancer cells when treated with poly(I:C).

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (27 results)

All 2013 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (22 results)

  • [Journal Article] The HSP70 and autophagy inhibitor pifithrin-mu enhances the antitumor effects of TRAIL on human pancreatic cancer2013

    • Author(s)
      Monma H, Harashima N, et al.
    • Journal Title

      Mol Cancer Ther

      Volume: 12 Issue: 4 Pages: 341-351

    • DOI

      10.1158/1535-7163.mct-12-0954

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor effects of cytoplasmic delivery of an innate adjuvant receptor ligand, poly(I : C), on human breast cancer2012

    • Author(s)
      Harada M., et al.(8人中8番目)
    • Journal Title

      Breast Cancer Research and Treatment

      Volume: (in press) Issue: 1 Pages: 89-100

    • DOI

      10.1007/s10549-011-1930-3

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Roles of the PI3 K/Akt pathway and autophagy in TLR3 sig naling-induced apoptosis and growth arr est of human prostate cancer cells2012

    • Author(s)
      Harashima, N., Inao, T., Imamura, R., et. al.
    • Journal Title

      Cancer Immunol. Immunother

      Volume: (in press) Issue: 5 Pages: 667-676

    • DOI

      10.1007/s00262-011-1132-1

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combining a peptide vaccine with oral ingestion of Lentinula edodes mycelia extract enhances anti-tumor activity in B16 melanoma-bearing mice2012

    • Author(s)
      Tanaka K, Harashima N, et al.
    • Journal Title

      Cancer Immunol Immunother

      Volume: 61 Issue: 11 Pages: 2143-2152

    • DOI

      10.1007/s00262-012-1275-8

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metronomic chemotherapy with low-dose cyclophosphamide plus gemcitabine can induce anti-tumor T cell immunity in vivo2012

    • Author(s)
      Miki Tongu, Nanae Harashima, Hiroyuki Monma, Touko Inao, Takaya Yamada, Hideyuki Kawauchi, Mamoru Harada
    • Journal Title

      Cancer Immunol Immunother

      Volume: 62 Issue: 2 Pages: 383-391

    • DOI

      10.1007/s00262-012-1343-0

    • NAID

      120005982738

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effect of pifithrin-mu, a new HSP70 and autophagy inhibitor, on TRAIL-induced apoptosis of pancreatic cancer cells2012

    • Author(s)
      門馬浩行, 原嶋奈々江 他
    • Organizer
      第71回日本癌学会
    • Place of Presentation
      ホテルロイトン札幌(北海道札幌市)
    • Year and Date
      2012-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Inhibition of autophagy augments cancer cell death induced by an adjuvant receptor ligand, poly(I:C)2012

    • Author(s)
      原嶋奈々江 他
    • Organizer
      第71回日本癌学会
    • Place of Presentation
      ホテルロイトン札幌(北海道札幌市)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Poly(I:C) トランスフェクションによるヒト腎癌細胞での ROSの産生とアポトーシスの誘導2012

    • Author(s)
      原嶋奈々江 他
    • Organizer
      第16回日本がん免疫学会
    • Place of Presentation
      北海道大学学術交流会館(北海道札幌市)
    • Year and Date
      2012-07-28
    • Related Report
      2012 Final Research Report
  • [Presentation] HSP70 および autophagy 阻害剤 pifithrin-mu はTRAIL によるヒト膵癌細胞の apoptosisを増強する2012

    • Author(s)
      門馬浩行, 原嶋奈々江 他
    • Organizer
      第16回日本がん免疫学会
    • Place of Presentation
      北海道大学学術交流会館(北海道札幌市)
    • Year and Date
      2012-07-26
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト乳癌細胞の抗癌剤抵抗性におけるオートファジーの役割2012

    • Author(s)
      稲尾瞳子, 原嶋奈々江 他
    • Organizer
      第20回日本乳癌学会
    • Place of Presentation
      熊本市民会館他(熊本)
    • Year and Date
      2012-06-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 膵臓癌細胞に対する TRAIL と HSP70 阻害剤pifithrin-mu 併用による抗腫瘍効果2012

    • Author(s)
      門馬浩行, 原嶋奈々江 他
    • Organizer
      第43回日本膵臓学会
    • Place of Presentation
      ホテルメトリポリタン山形(山形)
    • Year and Date
      2012-06-29
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト乳癌細胞の抗癌剤抵抗性におけるオートファジーの役割2012

    • Author(s)
      稲尾瞳子 他
    • Organizer
      第20回日本乳癌学会
    • Place of Presentation
      熊本市民会館、ホテル日航熊本 他(熊本市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 膵臓癌細胞に対するTRAIL とHSP70 阻害剤pifithrin-mu併用による抗腫瘍効果2012

    • Author(s)
      門馬浩行 他
    • Organizer
      第43回日本膵臓学会
    • Place of Presentation
      ホテルメトリポリタン山形(山形市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Poly(I:C) トランスフェクションによるヒト腎癌細胞でのROSの産生とアポトーシスの誘導2012

    • Author(s)
      原嶋奈々江 他
    • Organizer
      第16回日本がん免疫学会
    • Place of Presentation
      北海道大学学術交流会館(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] HSP70およびautophagy阻害剤 pifithrin-muはTRAILによるヒト膵癌細胞のapoptosisを増強する2012

    • Author(s)
      門馬浩行 他
    • Organizer
      第16回日本がん免疫学会
    • Place of Presentation
      北海道大学学術交流会館(札幌市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effect of pifithrin-mu, a new HSP70 and autophagy inhibitor, on TRAIL-induced apoptosis of pancreatic cancer cells2012

    • Author(s)
      門馬浩行 他
    • Organizer
      第71回日本癌学会
    • Place of Presentation
      ホテルロイトン札幌(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Inhibition of autophagy augments cancer cell death induced by an adjuvant receptor ligand, poly(I:C)2012

    • Author(s)
      原嶋奈々江 他
    • Organizer
      第71回日本癌学会
    • Place of Presentation
      ホテルロイトン札幌(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Role of autophagy in apoptosis of human cancer cells after stimulation through innate adjuvant receptors2011

    • Author(s)
      原田守,原嶋奈々江 他
    • Organizer
      第40回日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Apoptosis and ROS production in poly(I:C)-transfected human renal cell carcinoma2011

    • Author(s)
      原嶋奈々江 他
    • Organizer
      第40回日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Anti-tumor effect and autophagy in human breast cancer cells after the transfection with poly(I:C)2011

    • Author(s)
      稲尾瞳子, 原嶋奈々江 他
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Poly(I:C) transfection により誘導されるヒト乳癌細胞でのアポトーシスとオートファジー2011

    • Author(s)
      稲尾瞳子, 原嶋奈々江 他
    • Organizer
      第19回日本乳癌学会
    • Place of Presentation
      仙台国際センター(宮城)
    • Year and Date
      2011-09-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 乳癌細胞に発現するアジュバント受容体を利用し たimmunogenic cancer cell death の誘導2011

    • Author(s)
      原嶋奈々江 他
    • Organizer
      第15回日本がん免疫学会
    • Place of Presentation
      千里ライフサイエンスセンタービル(大阪)
    • Year and Date
      2011-06-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 乳癌細胞に発現するアジュバント受容体を利用した immunogenic cancer cell death の誘導2011

    • Author(s)
      原嶋奈々江 他
    • Organizer
      第15回日本がん免疫学会
    • Place of Presentation
      千里ライフサイエンスセンタービル(大阪)
    • Related Report
      2011 Research-status Report
  • [Presentation] Poly(I:C) transfectionにより誘導されるヒト乳癌細胞でのアポトーシスとオートファジー2011

    • Author(s)
      稲尾瞳子 他
    • Organizer
      第19回日本乳癌学会
    • Place of Presentation
      仙台国際センター(宮城)
    • Related Report
      2011 Research-status Report
  • [Presentation] Anti-tumor effect and autophagy in human breast cancer cells after the transfection with poly(I:C)2011

    • Author(s)
      稲尾瞳子 他
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Related Report
      2011 Research-status Report
  • [Presentation] Apoptosis and ROS production in poly(I:C)-transfected human renal cell carcinoma2011

    • Author(s)
      原嶋奈々江 他
    • Organizer
      第40回日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2011 Research-status Report
  • [Presentation] Role of autophagy in apoptosis of human cancer cells after stimulation through innate adjuvant receptors2011

    • Author(s)
      原田守 他
    • Organizer
      第40回日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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