Cancer cell death and autophagy induced by the signaling of immune adjuvant receptors
| Project/Area Number |
23701074
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor immunology
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 癌 / 免疫 / シグナル伝達 / アポトーシス / オートファジー |
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| Research Abstract |
An adjuvant receptor ligand, poly(I:C), is a well-known ligand for both an endosomal receptor TLR3 and a cytoplasmic receptor MDA-5, and can augment immune responses. Cancer cell death accompanying autophagy was induced in human prostate cancer cell line after poly(I:C) treatment. Poly (I:C) transfection into cytoplasminduced autophagy concurrently with apoptosis in human breast cancer cell lines. Blocking of autophagy significantly promoted cancer cell death after poly(I:C) transfection. These results indicate that autophagy plays a cytoprotective role in cell death of human prostate and breast cancer cells when treated with poly(I:C).
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Report
(3 results)
Research Products
(27 results)
