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Regulation of anti-tumor immunity by targeting cyclooxygenase-2 expressing cells

Research Project

Project/Area Number 23701076
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor immunology
Research InstitutionKyoto University (2012-2013)
Kitasato University (2011)

Principal Investigator

INOUE Joe  京都大学, 医学(系)研究科(研究院), 助教 (00433714)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordscox-2 / tumor / dendritic cell / liposome / COX-2
Research Abstract

The immunosuppression in tumor tissue has been attributed to tumor cells expressing cyclooxygenase (COX) -2. From this study, COX-2 was also expressed in tumor infiltrated CD11c+ cells. It was shown that through the production of immunosuppressive cytokines by COX-2+CD11c+ cells, the cells are largely responsible for immunosuppression in tumor tissues. Moreover, liposome (COX-2 selective inhibitors encapsulated liposome) which newly prepared to target the COX-2+CD11c+ cells, it showed the possibility to improve the immunosuppression by COX-2+CD11c + cells in tumor tissues.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (6 results)

All 2013 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Remarks (1 results)

  • [Journal Article] Liposomal lipopolysaccharide initiates TRIF-dependent signaling pathway independent of CD142013

    • Author(s)
      Watanabe S, Kumazawa Y, Inoue J
    • Journal Title

      PLoS One.

      Volume: 8(4)

    • NAID

      120005244422

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular delivery of lipopolysaccharide induces effective Th1-immune responses independent of IL-122013

    • Author(s)
      Watanabe S#, Inoue J#*
    • Journal Title

      PLoS One.

      Volume: 8(7)

    • NAID

      120005306995

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Liposomal lipopolysaccharide initiates TRIF-dependent signaling pathway independent of CD14.2013

    • Author(s)
      Watanabe S, Kumazawa Y, Inoue J
    • Journal Title

      PLoS One

      Volume: 8

    • NAID

      120005244422

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular delivery of lipopolysaccharide induces effective Th1-immune responses independent of IL-12.2013

    • Author(s)
      Watanabe S, Inoue J
    • Journal Title

      PLoS One

      Volume: 8

    • NAID

      120005306995

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liposomal lipopolysaccharide initiates TRIF-dependent signaling pathway independent of CD14.2013

    • Author(s)
      Sachiko Watanabe, Yoshio Kumazawa Y, Joe Inoue
    • Journal Title

      PLoS One

      Volume: 8 Issue: 4 Pages: e60078-e60078

    • DOI

      10.1371/journal.pone.0060078

    • NAID

      120005244422

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Remarks]

    • URL

      http://www.med.kyoto-u.ac.jp/organization-staff/research/doctoral_course/r-010/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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