Elucidation of tumor-associated macrophage accumulation mechanism accompanying tumor cell death

• Project/Area Number: 23701078
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor immunology
• Research Institution: Tokyo University of Pharmacy and Life Science
• Principal Investigator: NISHITAI Gen 東京薬科大学, 生命科学部, 助教 (60509941)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 細胞免疫 / マクロファージ

Research Abstract

Malignant tumors arise even in an immunocompetent host by outmaneuvering immune recognition. Accumulating evidence has suggested that tumor-associated macrophages (TAMs) play a key role in tumor growth. In the previous study, we revealed that TAMs were infiltrated to tumors in response to tumor cell death. To block the protumor function of TAMs, we established anti-S100A9 monoclonal antibody and revealed that tumor growth was suppressed by administrating anti-S100A9 monoclonal antibody