To identify the role of microRNA as a tumor suppressor in hematological malignancy

• Project/Area Number: 23701080
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor diagnosis
• Research Institution: Akita University
• Principal Investigator: WATANABE Atsushi 秋田大学, 医学部, 助教 (80567157)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: MicroRNA / 造血器腫瘍 / 悪性リンパ腫 / Mir-150 / 細胞老化 / microRNA / miR-150 / 多発性骨髄腫

Research Abstract

We analyzed aberrant expression of microRNAs in hematological malignancies. The levels of miR-150 expression in several lymphoma cell lines and clinical samples are significantly lower than in normal NK cells. We also found that miR-150 directly downregulates the expression of DKC1 and AKT2. These results suggest that miR-150 works as a tumor suppressor, and leading to telomerase activation. These findings provide new insight into the pathogenesis of malignant lymphoma.

Research Products

• [Journal Article] The role of miR-150 in malignant lymphoma (2011)
  • Author(s): Waatanabe A, Tagawa H, Takahashi N, et al.
  • Journal Title: Leukemia Volume: 25 Issue: 8 Pages: 1324-34
  • DOI: 10.1038/leu.2011.81
  • Peer Reviewed
• [Presentation] がん抑制的マイクロRNA-150のT細胞リンパ腫における役割 (2012)
  • Author(s): 伊藤貢
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2012-10-20
• [Presentation] The role of mir-150 as Tumor suppressor in malignant lymphoma (2011)
  • Author(s): 渡部敦,田川博之,手島和暁,奈良美保亀岡吉弘,高橋直人,久米正晃,清水則夫,澤田賢一
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-15
• [Presentation] The role of mir -150 as a tumor suppressor in NK/T cell lymphomaた (2011)
  • Author(s): 渡部敦,田川博之,澤田賢一
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-05
• [Presentation] The Role of Mir-150 as a Tumor Suppressor In NK/T cell lymphoma (2011)
  • Author(s): 渡部敦、田川博之、澤田賢一
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] The Role of Mir-150 as a Tumor Suppressor In Malignant Lymphoma (2011)
  • Author(s): 渡部敦、田川博之、手島和暁、奈 良美保、亀岡吉弘、高橋直人、久 米正晃、清水則夫、澤田賢一
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] がん抑制的マイクロRNA-150のＴ細胞リンパ腫における役割
  • Author(s): 伊藤 貢
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都国際会議場（京都市）