To identify the role of microRNA as a tumor suppressor in hematological malignancy
| Project/Area Number |
23701080
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Tumor diagnosis
|
|---|
| Research Institution | Akita University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
|---|
| Keywords | MicroRNA / 造血器腫瘍 / 悪性リンパ腫 / Mir-150 / 細胞老化 / microRNA / miR-150 / 多発性骨髄腫 |
|---|
| Research Abstract |
We analyzed aberrant expression of microRNAs in hematological malignancies. The levels of miR-150 expression in several lymphoma cell lines and clinical samples are significantly lower than in normal NK cells. We also found that miR-150 directly downregulates the expression of DKC1 and AKT2. These results suggest that miR-150 works as a tumor suppressor, and leading to telomerase activation. These findings provide new insight into the pathogenesis of malignant lymphoma.
|
Report
(3 results)
Research Products
(7 results)
