The development of the PET imaging diagnostic method based on metabolism properties of the malignant lymphoma

• Project/Area Number: 23701083
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor diagnosis
• Research Institution: Osaka University
• Principal Investigator: ISOHASHI Kayako 大阪大学, 大学院・医学系研究科, 助教 (50598604)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 悪性リンパ腫 / PET / ブドウ糖代謝 / 治療効果 / アミノ酸代謝 / PET-CT / PET-MRI / FDG / MET / 酢酸代謝

Research Abstract

Malignant lymphomas are characterized by repeated remissions and relapses. If the effect of treatment is able to be evaluated at an early stage, in the case that effect of treatment insufficiency is predicted, a regimen may be change and may improve a prognosis. In this study, metabolism images with PET and images with CT/MRI in the malignant lymphoma of the human and the small animal were compared and evaluated. We aim at the establishment of a more highly-detailed image evaluation system.

Research Products

• [Journal Article] Optimization of [11C]methionine PET study: appropriate scan timing and effect of plasma amino acid concentrations on the SUV. (2013)
  • Author(s): Isohashi K, Shimosegawa E, Kato H, Kanai Y, Naka S, Fujino K, Watabe H, Hatazawa J
  • Journal Title: EJNMMI Res. Volume: 3 Pages: 27-27
  • Peer Reviewed
• [Journal Article] Optimization of 11C-Methionine PET Study: Appropriate Scan timing and Effect of Plasma Amino Acid Concentrations on the SUV (2013)
  • Author(s): Kayako Isohashi
  • Journal Title: EJNMMI Research Volume: 未定
  • Peer Reviewed
• [Journal Article] 血液腫瘍におけるPET-CT の有用性 (2012)
  • Author(s): 礒橋佳也子 畑澤順
  • Journal Title: 日本成人病(生活習慣病)学会準機関誌 Volume: 42(6) Pages: 662-669
• [Journal Article] 日本成人病（生活習慣病）学会準機関誌 (2012)
  • Author(s): 礒橋佳也子
  • Journal Title: 血液腫瘍におけるPET-CTの有用性 Volume: 6 Pages: 8-8
• [Presentation] Prognostic value of imaging diagnosis on CT/MRI with International Working Group Criteria (IWC) and FDG-PET with Revised Response Criteria (RRC) in patients with malignant lymphoma (ML). (2013)
  • Author(s): Isohashi K,et al.
  • Organizer: SNMMI 2013 Annual Meeting
  • Place of Presentation: Vancouver (Canada)
  • Year and Date: 2013-06-10
• [Presentation] Prognostic value of imaging diagnosis on CT/MRI with International Working Group Criteria (IWC) and FDG-PET with Revised Response Criteria (RRC) in patients with malignant lymphoma (ML) (2013)
  • Author(s): Kayako Isohashi
  • Organizer: SNMMI 2013 Annual Meeting
  • Place of Presentation: Vancouver
• [Presentation] 悪性リンパ腫の治療効果判定と予後との関係 (2012)
  • Author(s): 礒橋佳也子
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: 札幌(北海道)
  • Year and Date: 2012-10-11
• [Presentation] 悪性リンパ腫の治療効果判定と予後との関係 (2012)
  • Author(s): 礒橋佳也子
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: ロイトン札幌
• [Presentation] 腫瘍患者における両側性かつ左右対称性の肺門及び縦隔リンパ節への11C-メチオニンの取り込み亢進の特徴 (2011)
  • Author(s): 礒橋佳也子
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば(茨城)
  • Year and Date: 2011-10-28
• [Presentation] Appropriate Scan Timing of C-11 methionine PET for SUV evaluation in various organs determinedby Dynamic whole-body 3D PET/CT. (2011)
  • Author(s): Isohashi K,et al.
  • Organizer: SNMMI 2011 Annual Meeting.
  • Place of Presentation: San Antonio, Texas(USA)
  • Year and Date: 2011-06-07
• [Presentation] Bilateral and symmetric pulmonary hilar and/or mediastinal lymphnode uptake of C-11methionine in oncologic patients associated with pulmonary inflammation. (2011)
  • Author(s): Isohashi K,et al.
  • Place of Presentation: San Antonio, Texas(USA)
  • Year and Date: 2011-06-07
• [Presentation] Appropriate Scan Timing of C-11 methionine PET for SUV evaluation in various organs determined by Dynamic whole-body 3D PET/CT (2011)
  • Author(s): 礒橋佳也子
  • Organizer: 米国核医学学会
  • Place of Presentation: San Antonio, Texas（USA）
• [Book] 「RADIONUCLIDE IMAGING IN THE ASSESSMENT OF RESPONSE TO ANTI-TUMOR TREATMENT'」. Nuclear Oncology (2014)
  • Author(s): Masahiro Yanagawa, Noriyuki Tomiyama, Tadashi Watabe, Kayako Isohashi, Jun Hatazawa
• [Book] Nuclear Oncology 「RADIONUCLIDE IMAGING IN THE ASSESSMENT OF RESPONSE TO ANTI-TUMOR TREATMENT'」 (2013)
  • Author(s): Masahiro Yanagawa
  • Total Pages: 77
  • Publisher: Nuclear Oncology