Development of HER2 targeted therapy for endometrial carcinoma
| Project/Area Number |
23701097
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical oncology
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| Research Institution | Kanazawa University |
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Principal Investigator |
MORI Noriko 金沢大学, 医学系, 協力研究員 (30579660)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 子宮内膜癌 / HER2 / 分子標的治療薬 |
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| Research Abstract |
Immunohistochemical analysis using surgical specimens of endometrial cancers showed a negative correlation between HER2 expression and phosphorylated (p)-mTOR but not p-AKT. Kaplan-Meier analysis revealed that high HER-2 expression appeared to be a risk factor of survival rate. Short interfering RNA (siRNA)-based knockdown of HER-2 reduced p-AKT expression and slightly increased sensitivity to MPA and paclitaxel (PTX) in endometrial cancer cells. Trastuzumab, anti-HER2 monoclonal antibody, enhanced sensitivity to low dose of PTX in endometrial cancer cells. This study suggested the efficacy of new HER2 targeted therapy for endometrial cancer.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Forkhead transcription factor FOXO1 is a direct target of progestin to inhibit endometrial epithelial cell growth2011
Author(s)
Kyo S, Sakaguchi J, Kiyono T, Shimizu Y, Maida Y, Mizumoto Y, Mori N, Nakamura M, Takakura M, Miyake K, Sakamoto M, Inoue M
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Journal Title
Clin Cancer Res
Volume: 17(3)
Issue: 3
Pages: 525-37
DOI
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Peer Reviewed
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[Presentation] 子宮内膜癌幹細胞における遺伝子解析の検討2011
Author(s)
中村充宏, 京 哲, 高倉正博, 毎田佳子, 水本泰成, 森 紀子, 保野由紀子, 井上正樹
Organizer
第63回日本産科婦人科学会学術講演会
Place of Presentation
リーガロイヤルホテル大阪および大阪国際会議場 (大阪府)
Year and Date
2011-08-30
Related Report
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