| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
Immunohistochemical analysis using surgical specimens of endometrial cancers showed a negative correlation between HER2 expression and phosphorylated (p)-mTOR but not p-AKT. Kaplan-Meier analysis revealed that high HER-2 expression appeared to be a risk factor of survival rate. Short interfering RNA (siRNA)-based knockdown of HER-2 reduced p-AKT expression and slightly increased sensitivity to MPA and paclitaxel (PTX) in endometrial cancer cells. Trastuzumab, anti-HER2 monoclonal antibody, enhanced sensitivity to low dose of PTX in endometrial cancer cells. This study suggested the efficacy of new HER2 targeted therapy for endometrial cancer.
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