Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma.
Project/Area Number |
23701098
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Clinical oncology
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Research Institution | Kanazawa University |
Principal Investigator |
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 肝細胞癌 / C19ORF10 / SAGE / SAGE法 |
Research Abstract |
This time, we succeeded in the full cloning of new molecular target C19ORF10 activated in hepatocellular carcinoma by the comprehensive gene analysis which used the SAGE library.C19ORF10 is a growth factor through PI3 K/Akt and MAPK/Erk1/2. Cancer cell growth was suppressed by adding the anti-C19ORF10 antibody. This result was submitted to International Journal of Cancer and published on Int J Cancer. 2011 Oct 1;129(7):1576-85. Furthermore, we created the ELISA plate to C19ORF10 serum-concentration measurement and examine to clinical application of C19ORF10.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism : a randomised controlled trial2014
Author(s)
Y Takeshita, T Takamura, M Honda, Y Kita, Y Zen, KI Kato, H Misu, T Ota, M Nakamura, K Yamada, H Sunagozaka, K Arai, T Yamashita, E Mizukoshi, S Kaneko
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Journal Title
Diabetologia
Volume: 57(5)
Issue: 5
Pages: 878-90
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Gene expression profiling of hepatitis B- and hepatitis C-related hepatocellular carcinoma using graphical Gaussian modeling.2013
Author(s)
Ueda T, Honda M, Horimoto K, Aburatani S, Saito S, Yamashita T, Sakai Y, Nakamura M, Takatori H, Sunagozaka H, Kaneko S.
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Journal Title
Genomics.
Volume: Apr;101(4)
Issue: 4
Pages: 238-48
DOI
Related Report
Peer Reviewed
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[Journal Article] Slowly progressive insulin-dependent diabetes in a patient with primary biliary cirrhosis with portal hypertension-type progression2012
Author(s)
Takeshita Y, Takamura T, Inoue O, Okumura,Kato K, Sunagozaka H, Arai K, Misu H, Nakamura M, Nakanuma Y, Kaneko S
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Journal Title
Intern Med
Volume: 51(1)
Pages: 79-82
NAID
Related Report
Peer Reviewed
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[Journal Article] Beneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance : implications fortype 2 diabetes2012
Author(s)
Takeshita Y, Takamura T, Kita Y, Ando H, Ueda T, Kato K, Misu H, Sunagozaka H, Sakai Y,Yamashita T, Mizukoshi E, Honda M, Kaneko S
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Journal Title
Metabolism.
Volume: 61(10)
Pages: 1388-94
Related Report
Peer Reviewed
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[Journal Article] Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development.2012
Author(s)
Okada H, Honda M, Campbell JS, Sakai Y, Yamashita T, Takebuchi Y, Hada K, Shirasaki T, Takabatake R, Nakamura M, Sunagozaka H, Tanaka T, Fausto N, Kaneko S.
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Journal Title
Cancer Res.
Volume: 72
Issue: 17
Pages: 4459-4471
DOI
Related Report
Peer Reviewed
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[Journal Article] Slowly progressive insulin-dependent diabetes in a patient with primary biliary cirrhosis with portal hypertension-type progression.2012
Author(s)
Takeshita Y, Takamura T, Inoue O, Okumura M, Kato K, Sunagozaka H, Arai K, Misu H, Nakamura M, Nakanuma Y, Kaneko S.
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Journal Title
Intern Med.
Volume: 51(1)
Pages: 79-82
NAID
Related Report
Peer Reviewed
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[Journal Article] Beneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance: implications for type 2 diabetes.2012
Author(s)
Takeshita Y, Takamura T, Kita Y, Ando H, Ueda T, Kato K, Misu H, Sunagozaka H, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S.
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Journal Title
Metabolism
Volume: 61(10)
Pages: 1388-94
NAID
Related Report
Peer Reviewed
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[Journal Article] Slowly progressive insulin-dependent diabetes in a patient with primary biliary cirrhosis with portal hypertension-type progression.2012
Author(s)
Takeshita Y, Takamura T, Inoue O, Okumura M, Kato K, Sunagozaka H, Arai K, Misu H, Nakamura M, Nakanuma Y, Kaneko S.
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Journal Title
Intern Med
Volume: 51(1)
Pages: 79-82
NAID
Related Report
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[Journal Article] Randomized, phase II study comparing interferon combined with hepatic arterial infusion of fluorouracil plus cisplatin and fluorouracil alone in patients with advanced hepatocellular carcinoma.2011
Author(s)
Yamashita T, Arai K, Sunagozaka H, Ueda T, Terashima T, Yamashita T, Mizukoshi E, Sakai A, Nakamoto Y, Honda M, Kaneko S.
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Journal Title
Oncology
Volume: 81(5-6)
Pages: 281-90
NAID
Related Report
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[Presentation] Serum Dickkopf-1 as a biomarker for the diagnosis of hepatocellular carcinoma with stemcell features2013
Author(s)
Hajime Sunagozaka, Taro Yamashita, Naoki Oishi, Takehiro Hayashi, Hajime Takatori, Tetsuro Shimakami, Kazuya Kitamura, Kuniaki Arai, Takashi Kagaya, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda,Shuichi Kaneko
Organizer
第64回米国肝臓学会
Place of Presentation
Washington D.C(USA)
Year and Date
2013-11-05
Related Report
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[Presentation] ソラフェニブ治療後症例に対する肝動注化学療法の安全性と有効性に関する検討2013
Author(s)
砂子阪肇,山下竜也,荒井邦明,堀井里和,飯田宗穂,北原征明,大石尚毅,鷹取元,島上哲朗,北村和哉,加賀谷尚史,山下太郎,酒井佳夫,水腰英四郎,金子周一
Organizer
第8回日本肝がん分子標的治療研究会
Place of Presentation
和倉温泉「加賀屋」(石川)
Year and Date
2013-06-22
Related Report
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[Presentation] Serum Dickkopf-1 as a biomarker for the diagnosis of hepatocellular carcinoma with stem cell features2013
Author(s)
Hajime Sunagozaka, Taro Yamashita, Naoki Oishi, Takehiro Hayashi, Hajime Takatori, Tetsuro Shimakami, Kazuya Kitamura, Kuniaki Arai, Takashi Kagaya, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko
Organizer
第64回米国肝臓学会
Place of Presentation
Washington D.C, USA
Related Report
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