Study for post-operative adjuvant therapy choice by using autoantibodies in patients with breast cancer
| Project/Area Number |
23701100
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical oncology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
TAMESA Michiko 山口大学, 医学部付属病院, 医師 (10570822)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 乳癌 / 自己抗体 / プロテオミクス / 二次元電気泳動 |
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| Research Abstract |
Protein samples from breast cancer tissues and paired non-cancerous tissues were analyzed by two-dimensional gel electrophoresis. After reaction with sera from patients with breast cancer or cancer-free patients, 10 spots which reacted to auto-antibodies from patients with breast cancer and not reacted to control sera were detected. Mass spectrometry analysis by LC-MS/MS identified three spots such as peptidyl-prolyl cis-trans isomerase A, but the other spots were not identified. Further studies for identifying the other spots are expectable.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Germline copy number variations associated with breast cancer susceptibility in a Japanese population.2013
Author(s)
Suehiro Y, Okada T, Shikamoto N, Zhan Y, Sakai K, Okayama N, Nishioka M, Furuya T, Oga A, Kawauchi S, Maeda N, Tamesa M, Nagashima Y, Yamamoto S, Oka M, Hinoda Y, Sasaki K
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Journal Title
Tumour Biol
Volume: 34(2)
Issue: 2
Pages: 947-952
DOI
Related Report
Peer Reviewed
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