Therapeutic strategy for gastric cancer using apoptosis activating small molecule

• Project/Area Number: 23701101
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Clinical oncology
• Research Institution: Saga University
• Principal Investigator: IDE Takao 佐賀大学, 医学部, 助教 (40587549)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 小分子化合物 / アポトーシス

Research Abstract

Peritoneal dissemination from gastric cancer is lethal disease, therefore understanding such molecular mechanism and establishment of new therapeutic strategy is essential. PPLGM, a small molecule which we discovered,has anti-tumor effect in gastric cancer cells through activating apoptosis pathway. Our study suggested the possibility that PPLGM is one of key drug for gastric cancer.

Research Products

• [Journal Article] Loss of trefoil factor 1 is regulated by DNA methylation and is an independent predictive factor for poor survival in advanced gastric cancer (2013)
  • Author(s): Tanaka T, Nakamura J, Kitajima Y, Kai K, Miyake S, Hiraki M, ide T, Koga Y, Noshiro H
  • Journal Title: INTERNATIONAL JOURNAL OF ONCOLOGY Volume: 42 3 Pages: 894-902
  • Peer Reviewed
• [Journal Article] Primary squamous cell carcinoma of the liver concomitant with primary colon cancer : report of a case (2013)
  • Author(s): Kiyoto Morito,Keita Kai,Atsushi Miyoshi,Hiroshi Kubo,Takao ide,Shinya Azama,Hiroyuki Irie,Yasuo Koga,Kenji Sumi,Osamu Ikeda,Kenji Kitahara,Hirokazu Noshiro
  • Journal Title: Clinical Journal of Gastroenterology Volume: 62 Pages: 134-138
  • Peer Reviewed
• [Journal Article] Appraisal of simultaneous laparoscopic splenectomy and hepatic resection in the treatment of hepatocellular carcinoma with hypersplenic thrombocytopenia (2013)
  • Author(s): Miyoshi A, ide T, Kitahara K, Noshiro H
  • Journal Title: Hepatogastroenterology Volume: Aug 9;60(127) [Epub ahead of print]
  • Peer Reviewed
• [Journal Article] Mitotic count reflects prognosis of gallbladder cancer partlarly among patients with T3 tumor (2013)
  • Author(s): Keita kai ,Masanori Masuda, Takao ide,Yukari Takase, Atsushi Miyoshi, Kenji Kitahara, Kohji Miyazaki,Hirokazu noshiro, and Osamu Tokunaga
  • Journal Title: MOLECULAR AND CLINICAL ONCOLOGY Volume: 1 Pages: 633-638
  • Peer Reviewed
• [Journal Article] Actual status of clinical diagnosis in patients with primary gallbladder cancer associated with adenomyomatosis (2013)
  • Author(s): Kai K, Irie H, ide T, Masuda M, Kitahara K, Miyoshi A, Miyazaki K, Noshiro H, Tokunaga O
  • Journal Title: Indian J Gastroenterol Volume: 32 6 Pages: 386-391
  • Peer Reviewed
• [Journal Article] A case of mucinous cholangiocarcinoma showing features of hepatocellular carcinoma (2013)
  • Author(s): Kai K, ide Y, Miyoshi A, Masuda M, ide T, Kitahara K, Irie H, Nakajima J, Noshiro H, Tokunaga O
  • Journal Title: Pathology International Volume: 63 8 Pages: 419-421
  • Peer Reviewed
• [Journal Article] Prediction of postoperative complications in elderly patients with hepatocellular carcinoma (2013)
  • Author(s): Ide T, Miyoshi A, Kitahara K, Noshiro H
  • Journal Title: Journal of Surgical Research Volume: 185 Pages: 614-619
  • Peer Reviewed
• [Journal Article] 胆嚢腺筋腫症に発生した胆嚢肉腫様癌の1例 (2013)
  • Author(s): 江川紀幸、井手貴雄、甲斐敬太、三好篤、北原賢二、能城浩和
  • Journal Title: 日本消化器外科学会雑誌 Volume: 46 4 Pages: 275-281
  • Peer Reviewed
• [Journal Article] AZE VirtualPlaceを用いた術前肝切除シュミレーションの有用性 (2012)
  • Author(s): 三好篤、古賀浩木、中村淳、井手貴雄、北原賢二、能城浩和
  • Journal Title: INNERVISION Volume: 28 1 Pages: 94-95
  • Peer Reviewed
• [Journal Article] Hepatoid carcinoma of the pancreas penetrating into the gastric cavity : A case report and literature review (2012)
  • Author(s): Keita Kai, Jun Nakamura, Takao ide, Masanori Masuda, Kenji Kitahara, Atsushi Miyoshi, Hirokazu Noshiro and Osamu Tokunaga
  • Journal Title: Pathology International Volume: 62 Pages: 485-490
  • Peer Reviewed
• [Journal Article] Spindle and Giant Cell Type Undifferentiated Carcinoma of the Proximal Bile Duct (2012)
  • Author(s): Takao ide Atsushi Miyoshi Kenji Kitahara Keita Kai, b Hirokazu Noshiro
  • Journal Title: Case Reports in Gastroenterology Volume: 6 Pages: 33-39
  • Peer Reviewed
• [Journal Article] Tumor budding and dedifferentiation in gallbladdercarcinoma : potential for the prognostic factors in T2 lesions (2011)
  • Author(s): Keita Kai、 Naohiko Kohya、Kenji Kitahara、 Masanori Masuda、 Atsushi Miyoshi Takao ide ,Osamu Tokunaga ,Kohji Miyazaki Hirokazu Noshiro
  • Journal Title: Virchows Arch Volume: 459 Pages: 449-456
  • Peer Reviewed
• [Journal Article] 腹腔鏡下手術後ドレーン抜去孔に発生した5mmポートサイトヘルニア嵌頓の1例 (2011)
  • Author(s): 井手貴雄、鮫島隆一郎、酒井正、井久保丹、田渕正延、湯ノ谷誠二
  • Journal Title: 外科 Volume: 73 11 Pages: 1237-1240
  • Peer Reviewed
• [Journal Article] Selective killing of cancer cells by a small molecule targeting the stress response to ROS (2011)
  • Author(s): Raj L, ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW
  • Journal Title: Nature Volume: Jul 13;475(7355) Pages: 231-4
  • Peer Reviewed
• [Journal Article] Clinicopathologic features of advanced gallbladder cancer associated with adenomyomatosis (2011)
  • Author(s): Kai K, ide T, Masuda M, Kitahara K, Miyoshi A, Miyazaki K, Noshiro H, Tokunaga O
  • Journal Title: Virchows Arch. Volume: Dec;459(6) (Epub 2011 Oct 26) Pages: 573-80
  • Peer Reviewed
• [Journal Article] Selective killing of cancer cells by a small molecule targeting the stress response to ROS (2011)
  • Author(s): Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW
  • Journal Title: Nature Volume: 475 Pages: 231-234
  • Peer Reviewed
• [Presentation] エネルギー代謝制御破綻による大腸癌悪性形質進展機序 (2011)
  • Author(s): 井手貴雄、Sam W Lee、古賀靖大、能城浩和、宮﨑耕治
  • Organizer: 第22回日本消化器癌発生学会総会